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G Protein Coupled Receptors: Modeling, Activation, Interactions and Virtual Screening de P. Michael Conn

G Protein Coupled Receptors: Modeling, Activation, Interactions and Virtual Screening: Methods in Enzymology, cartea 522

P. Michael Conn
en Limba Engleză Hardback – 25 mar 2013
This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation.


  • Continues the legacy of this premier serial with quality chapters authored by leaders in the field
  • Covers G protein coupled receptors
  • Contains chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation
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Specificații

ISBN-13: 9780124078659
ISBN-10: 0124078656
Pagini: 528
Dimensiuni: 152 x 229 x 27 mm
Ediția:New.
Editura: ELSEVIER SCIENCE
Seria Methods in Enzymology

Public țintă

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Cuprins

GPCR Modeling
  1. The Protein Local Optimization Program and G-Protein Coupled Receptors: Loop Restoration and Applications to Homology Modeling
  2. Modeling Active GPCR Conformations
  3. Molecular Modeling of Adenosine Receptors
  4. Predicting G Protein-Coupled Receptors Families using Different Physiochemical Properties and Pseudo Amino Acid Composition Computational Design and Experimental Characterization of GPCR Segment Models
    GPCR Interactions with Other Molecules and Cross-Talk
  5. G Protein-Coupled Receptor Interaction with Small GTPases
  6. Quantification of Receptor Tyrosine Kinase Activation and Transactivation by G Protein Coupled Receptors Using Spatial Intensity Distribution Analysis (SpIDA)
  7. NMR Methods for Detection of Small Molecule Binding to RGS4
  8. Group II Activators of G-protein Signaling: Monitoring the Interaction of Ga with the G-Protein Regulatory Motif in the Intact Cell
  9. Homogeneous Time-Resolved Fluorescence Assay to Probe Folded G Protein-Coupled Receptors
  10. cAMP Biosensors Applied in Molecular Pharmacological Studies of G Protein-Coupled Receptors
  11. Rhodopsin-Lipid Interactions Studied by NMRGPCR Bias
  12. Biasing the Parathyroid Hormone Receptor: Relating In Vitro Ligand Efficacy to In Vivo Biological ActivityVirtual Screening
  13. Application of Monte Carlo-based Receptor-Ensemble Docking to Virtual Screening for GPCR Ligands
  14. From Heptahelical Bundle to Hits from the Haystack: Structure-Based Virtual Screening for GPCR LigandsGPCR Activation
  15. Kinetics and Dynamics in the G-Protein Coupled Receptor Signaling Cascade
  16. Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of G Protein-Coupled Receptors
  17. Post-Translation Modification of G Protein-Coupled Receptor in Relationship to Biased Agonism
  18. Protein S-Nitrosylation Measurement