Protein Kinase Inhibitors in Research and Medicine
Kevan M Shokaten Limba Engleză Hardback – 11 noi 2014
- Continues the legacy of this premier serial with quality chapters authored by leaders in the field
- Covers research methods in biomineralization science
- Contains sections focusing on protein kinase inhibitors in research and medicine
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Specificații
ISBN-13: 9780123979186
ISBN-10: 0123979188
Pagini: 252
Dimensiuni: 152 x 229 x 19 mm
Greutate: 0.52 kg
Editura: ELSEVIER SCIENCE
ISBN-10: 0123979188
Pagini: 252
Dimensiuni: 152 x 229 x 19 mm
Greutate: 0.52 kg
Editura: ELSEVIER SCIENCE
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Public țintă
Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologistsCuprins
1. Catalytic Mechanisms and Regulation of Protein Kinases
Zhihong Wang and Philip A. Cole.
2. A Structural Atlas of Kinases Inhibited by Clinically Approved Drugs
Qi Wang, Julie A. Zorn and John Kuriyan.
3. Fragment-Based Approaches to the Discovery of Kinase Inhibitors
Paul N. Mortenson, Valerio Berdini and Marc O’Reilly.
4. Targeting Protein Kinases with Selective and Semi-Promiscuous Covalent Inhibitors
Rand M. Miller and Jack Taunton.
5. The Resistance Tetrad: Amino Acid Hotspots for Kinome-Wide Exploitation of Drug-resistant Protein Kinase Alleles
Veselin I Andreev and Patrick A Eyers
6. FLiK: A Direct Binding Assay for the Identification and Kinetic Characterization of Stabilizers of Inactive Kinase Conformations
Jeffrey R. Simar and Daniel Rauh
7. Discovery of Allosteric Bcr-Abl inhibitors from Phenotypic Screen to Clinical Candidate
Nathanael S. Gray and Doriano Fabbro
8. The Logic and Design of Analog-Sensitive (AS) Kinases and their Small Molecule Inhibitors
Michael S. Lopez, Joseph Kliegman and Kevan M. Shokat
Zhihong Wang and Philip A. Cole.
2. A Structural Atlas of Kinases Inhibited by Clinically Approved Drugs
Qi Wang, Julie A. Zorn and John Kuriyan.
3. Fragment-Based Approaches to the Discovery of Kinase Inhibitors
Paul N. Mortenson, Valerio Berdini and Marc O’Reilly.
4. Targeting Protein Kinases with Selective and Semi-Promiscuous Covalent Inhibitors
Rand M. Miller and Jack Taunton.
5. The Resistance Tetrad: Amino Acid Hotspots for Kinome-Wide Exploitation of Drug-resistant Protein Kinase Alleles
Veselin I Andreev and Patrick A Eyers
6. FLiK: A Direct Binding Assay for the Identification and Kinetic Characterization of Stabilizers of Inactive Kinase Conformations
Jeffrey R. Simar and Daniel Rauh
7. Discovery of Allosteric Bcr-Abl inhibitors from Phenotypic Screen to Clinical Candidate
Nathanael S. Gray and Doriano Fabbro
8. The Logic and Design of Analog-Sensitive (AS) Kinases and their Small Molecule Inhibitors
Michael S. Lopez, Joseph Kliegman and Kevan M. Shokat