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Introduction to Protein Structure de Carl Ivar Branden

Introduction to Protein Structure

Autor Carl Ivar Branden, John Tooze
en Limba Engleză Paperback – 1999
Introduction to Protein Structure provides an account of the principles of protein structure, with examples of key proteins in their biological context generously illustrated in full-color to illuminate the structural principles described in the text. The first few chapters introduce the general principles of protein structure both for novices and for non-specialists needing a primer. Subsequent chapters use specific examples of proteins to show how they fulfill a wide variety of biological functions. The book ends with chapters on the experimental approach to determining and predicting protein structure, as well as engineering new proteins to modify their functions.
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Specificații

ISBN-13: 9780815323051
ISBN-10: 0815323050
Pagini: 424
Ilustrații: colour illustrations
Dimensiuni: 219 x 276 x 17 mm
Greutate: 1.64 kg
Ediția:Revizuită
Editura: CRC Press
Colecția Garland Science

Cuprins

PART 1 BASIC STRUCTURAL PRINCIPLES
1. The Building Blocks
2. Motifs of Protein Structure
3. α-Domain Structures
4. α/β Structures
5. β Structures
6. Folding and Flexibility
7. DNA Structures  
PART 2 STRUCTURE, FUNCTION AND ENGINEERING 
8. DNA Recognition in Procaryotes by Helix-Turn-Helix Motifs
9. DNA Recognition by Eukaryotic Transcription Factors
10. Specific Transcription Factors Belong to a Few Families
11. An Example of Enzyme Catalysis: Serine Proteinases 
12. Membrane Proteins
13. Signal Transduction
14. Fibrous Proteins
15. Recognition of Foreign Molecules by the Immune System
16. The Structure of Spherical Viruses
17. Prediction, Engineering, and Design of Protein Structures
18. Determination of Protein Structures

Notă biografică

Carl Branden was educated at Uppsala University (PhD) and the MRC Laboratory for Molecular Biology, Cambridge, where he was a postdoctoral fellow in the laboratory of J.C. Kendrew. He has pursued a career in basic research, science administration (as science advisor to the Swedish Government), and biotechnology. Formerly Research Director of the European Synchrotron Radiation Facility in Grenoble, France, he is now at the Microbiology and Tumor Biology Center at the Karolinska Institute in Stockholm. A protein crystallographer with a distinguished academic career in research and teaching, he has made major contributions to the understanding of many biological structures, and is an editor of Structure.
John Tooze was educated at Cambridge University (MA), London University (PhD) and Harvard University (where he was a postdoctoral fellow in the laboratory of J.D. Watson). After several years in basic research, he moved principally into science administration and science publishing, notably as the executive secretary of the European Molecular Biology Organisation, Heidelberg, Germany. He is currently Director of Support Services at the Imperial Cancer Research Fund Laboratories, London, and editor of EMBO Journal. A molecular biologist, his previous books include Molecular Biology of Tumor Viruses, The DNA Story (with J.D. Watson) and the very successful first edition of Recombinant DNA: A Short Course (with J.D. Watson and D.T. Kurtz).

Recenzii

"The strength of the book lies in its beautiful art work and its logical dissection of the baffling complexities of protein structures…admirably concise, lucid and accurate presentations of difficult concepts…invaluable for students…" Nature"As an introduction to what proteins look like, how they fold up and how they interact with other molecules, large and small this book has no peer. It will be invaluable to students and research workers." Trends in Biotechnical Sciences
"As usual, the distillation is authoritative and breathtaking." Tom Alber, University of California, Berkeley
"It is superb. It gives a terrific overview, with great breadth and a proper and fair weight to the subject it treats." Ken Dill, University of California, San Francisco

Descriere

A contemporary account of the principles of protein structure, with examples of proteins in their biological context. Includes chapters on the general principles, specific examples of structures and on determining and predicting.