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Biotechnology of Plasma Proteins de Roger L. Lundblad

Biotechnology of Plasma Proteins: Protein Science

Autor Roger L. Lundblad
en Limba Engleză Hardback – 8 aug 2012
The fractionation of human blood plasma can be considered to be a mature industry, with the basic technology, alcohol fractionation, dating back at least to the 1940s. Many of the products described in the current work have been approved biologics since the 1950s. The information gathered from the development of plasma proteins has proved vital to the development of recombinant therapeutic proteins.
Discussing the role of plasma proteins in current biotechnology, Biotechnology of Plasma Proteins describes the protein composition of human plasma, the fractionation of plasma to obtain therapeutic proteins, and the analysis of these products. It delineates the path from plasma products to recombinant products, and highlights products from albumin, intravenous immunoglobins, and coagulation. It offers a comprehensive review of current techniques for the analysis of proteins including electrophoresis, chromatography, spectrophotometry, mass spectrometry, and updates not published since 1975.
Key Topics
Protein Composition of Plasma
  • Proteomic methods for plasma protein analysis
  • Plasma protein biomarkers
  • Validation of biomarkers
  • Assays for plasma biomarkers
Methods for the Analysis of Protein Products
  • Assay development and validation
  • Electrophoresis
  • Chromatography
  • Immunoassay
  • Mass spectrometry
  • Raman spectroscopy
Plasma Fractionation: Historical and Modern Methods
  • Development of Cohn alcohol fractionation
  • Industrial methods
  • Development of chromatographic methods
Plasma Protein Products of Therapeutic Value
  • Albumin
  • Intravenous immunoglobulin
  • Coagulation products
  • Growth factors
  • Wound management
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Specificații

ISBN-13: 9781439850268
ISBN-10: 1439850267
Pagini: 460
Ilustrații: 20 black & white illustrations, 10 black & white tables
Dimensiuni: 152 x 229 x 33 mm
Greutate: 0.77 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Seria Protein Science

Cuprins

Blood, Plasma, Cells, and Other Biological Fluids. Plasma Fractionation and Plasma Protein Products. Methods for the Analysis of Plasma and Plasma Protein Fractions. Albumin. Plasma Immunoglobulins. Factor VIII and von Willebrand Factor. Plasma Proteinase Inhibitors. Vitamin K-Dependent Proteins. Miscellaneous Plasma Proteins.

Descriere

Discussing the role of plasma proteins in current biotechnology, this book describes the protein composition of human plasma, the fractionation of plasma to obtain therapeutic proteins, and the analysis of these products. It delineates the path from plasma products to recombinant products, and highlights products from albumin, intravenous immunoglobins, and coagulation. It offers a comprehensive review of current techniques for the analysis of proteins including electrophoresis, chromatography, spectrophotometry, and mass spectrometry, as well as updates not published since 1975.