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Gene Transfer Vectors for Clinical Application de Theodore C. Friedman

Gene Transfer Vectors for Clinical Application: Methods in Enzymology, cartea 507

Theodore C. Friedman
en Limba Engleză Hardback – 17 apr 2012
This volume of Methods in Enzymology looks at Gene Transfer Vectors for Clinical Application. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume covers such topics as General principles of retrovirus vector design, Chronic granulomatous disease (CGD), Gene therapy for blindness, and Retrovirus genetic strategy and vector design.


  • Chapters provide an invaluable resource for academics, researchers and students alike
  • International board of authors
  • This volume covers such topics as general principles of retrovirus vector design, chronic granulomatous disease (CGD), gene therapy for blindness, and retrovirus genetic strategy and vector design
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Specificații

ISBN-13: 9780123865090
ISBN-10: 0123865093
Pagini: 440
Dimensiuni: 152 x 229 x 28 mm
Greutate: 0.8 kg
Editura: ELSEVIER SCIENCE
Seria Methods in Enzymology

Public țintă

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Cuprins

Preface: The successful clinical use of viral vectors for human gene therapy.
  1. General principles of retrovirus vector design
  2. Strategies for retrovirus-based correction of severe, combined immunodeficiency (SCID)
  3. Retrovirus and lentivirus vector design and methods of cell conditioning
  4. Analysis of the clonal repertoire of gene corrected cells in gene therapy
  5. Developing novel lentiviral vectors into clinical products
  6. Lentivirus vectors in beta-thalassemia
  7. Gene Therapy for Chronic Granulomatous Disease
  8. Alternative splicing caused by lentiviral integration in the human genome
  9. Genotoxicity assay for gene therapy vectors in tumor prone Cdkn2a-/- mice
  10. Lentiviral Hematopoietic Cell Gene Therapy for X-linked Adrenoleukodystrophy
  11. Retroviral replicating vectors in cancer
  12. Adeno-associated virus vectorology, manufacturing and clinical applications
  13. Gene Delivery To The Retina: From Mouse To Man
  14. Generation of hairpin-based RNAi vectors for biological and therapeutic application
  15. Recombinant adeno-associated viral vector reference standards
  16. NIH oversight of human gene transfer research involving retroviral, lentiviral and adeno-associated virus vectors and the role of the NIH recombinant DNA advisory committee draft
  17. Regulatory structures for gene therapy medicinal products in the European Union