This edited book takes a critical look at the geopolitics of the broader Middle East and North Africa (MENA) region. It scrutinizes some of the perennial issues shaping the regional security agenda, as well as the emerging geopolitical trends in the wake of a decade of turmoil triggered by the demands for political and economic reforms. The contributors explore the geopolitical implications of the structural transformation process in the MENA region and beyond, which has unleashed destabilizing forces and multifaceted conflicts, with the involvement of many local, regional and global actors. They also look at how some of the regional actors have reacted to the risks and security challenges produced by the wave of instability and conflicts, and conducted their foreign policy in this volatile period of fluid alliances. Other contributors explore the roles and perspectives of major extra-regional actors, delving deeper into how they have adjusted their policies towards the emergence of a new order and reshuffling of alignments. This book will be of interest to researchers and advanced students of politics, international relations, and political geography. It was originally published as a special issue of the Journal of Balkan and Near Eastern Studies.