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Handbook of Biomarkers and Precision Medicine de Claudio Carini

Handbook of Biomarkers and Precision Medicine

Editat de Claudio Carini, Mark Fidock, Alain van Gool
en Limba Engleză Paperback – 18 dec 2020
"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health


Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development.


Features:







  • Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies







  • Lessons-learned from successful Precision Medicine case studies







  • A variety of exciting and emerging biomarker technologies







  • The next frontiers and future challenges of biomarkers in Precision Medicine




Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.


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Specificații

ISBN-13: 9780367730055
ISBN-10: 0367730057
Pagini: 657
Dimensiuni: 210 x 280 x 34 mm
Greutate: 2.13 kg
Ediția:1
Editura: CRC Press
Colecția Chapman and Hall/CRC

Cuprins

Introduction. What is a Biomarker and its Role in Drug Development? Biomarkers in Discovery and PreClinical Safety. Translating From Pre-Clinical Results to Clinical and Back. Biomarkers in Clinical Trials -Design Considerations for Biomarker Informed Clinical Trials. The road ahead: Identification of the hurdles and solutions to the implementation of personalized medicine in healthcare. Lessons from the past and pioneers of the future. Paving a new era of personalized medicine: Emerging technologies. The next frontiers of therapeutic target areas: Autoimmunity, inflammation, respiratory, metabolic, cardiovascular and neurological diseases. Lessons Learned: What have we learned and what is the next challenge?

Recenzii

"This handbook is hardcover and was published at CRC Press / Taylor and Francis Group in 2019. From the first time I opened it, I could notice that the printing and quality of paper is exceptional. The handbook has 631 pages and very nicely coloured figures, schemes and drawings, that are very easily understandable and very helpful in processing the text of the handbook. The field of biomarkers is approached in this book in a scholastic manner, starting from the first discovery and use of biomarkers to the regulatory approaches in the field of precision medicine, passing from preclinical studies, translational medicine, clinical trials, and implementation in practice. Several case-studies are presented related to HIV diagnosis, infertility, coagulation, BRCA identification, but also case-studies related to biomarker-based clinical trials... This handbook is complete, exact, succinct and unique, and gathers information from different perspectives, useful to different players from the field of biomarkers in precision medicine, making it a an excellent tool for learning. First of all, I would recommend this handbook to researchers from the medical and connected fields. It could help the development of this engaging field of personalized care due to highly accurate and relevant data presented by the authors. Secondly, I would recommend it to medical doctors from all specialties since it offers a deep and comprehensive approach into a field that only a few decades ago was hardly recognized and since the practice of medicine in most specialties during the following years will, for sure, include a personalized approach to
patients. Both these addressees, researchers and medical practitioners, can make a difference. Least but not last, I would say that even residents and medical students would benefit from the comprehensive approach that this book provides."
- Costela Serban, ISCB December 2019

Notă biografică

Claudio Carini, Mark Fidock, Alain van Gool

Descriere

Provides perspective, covers recent developments in technologies that have enabled the expanded use of biomarkers, discusses biomarker characterization and validation, and applications throughout the discovery-development continuum, including Companion Diagnostic ( CDX) development.