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Haploidentical Transplantation: Concepts & Clinical Application de Stefan O. Ciurea

Haploidentical Transplantation: Concepts & Clinical Application: Advances and Controversies in Hematopoietic Transplantation and Cell Therapy

Editat de Stefan O. Ciurea, Rupert Handgretinger
en Limba Engleză Paperback – 4 ian 2019
In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant and readily applicable information. Among the areas covered are graft manipulation and methods to control T-cell alloreactivity, the nature of the ideal graft and donor, haploidentical transplantation in pediatric and adult patients with malignant and nonmalignant diseases, immunologic reconstitution following transplantation, complications, and the prevention and treatment of relapse post transplantation. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. The book will provide practical support for hematologists and transplant physicians as they attempt to provide optimal care in this exciting but increasingly complex medical specialty.
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Specificații

ISBN-13: 9783030096113
ISBN-10: 3030096114
Pagini: 337
Ilustrații: XI, 337 p. 25 illus., 18 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.54 kg
Ediția:Softcover reprint of the original 1st ed. 2018
Editura: Springer International Publishing
Colecția Springer
Seria Advances and Controversies in Hematopoietic Transplantation and Cell Therapy

Locul publicării:Cham, Switzerland

Cuprins

Historical perspective and current trends in haploidentical transplantion.- Part 1: Graft manipulation and methods to control T-cell alloreactivity. -Positive CD34+ cell selection.- Selective allo-depletion: αβ and CD19+ cell  T cell depletion.- T cell addback in T- cell depleted haploidentical transplant.- Hematopoietic myeloid growth factor primed bone marrow and peripheral blood hematopoietic progenitor cells.- Photodepletion of allo-reactive T cells.- Post-transplant cyclophosphamide in haploidentical transplant.- Part 2: Ideal graft & donor.- Graft source: Marrow versus peripheral blood with PTCy- Does it matter?.- Anti-HLA antibodies: Assessment and mitigating strategies.- Selection of haploidentical donors: What is the art?.- Myeloablative versus non-myeloablative conditioning regimen- Does it matter and how best to select?.- Part 3: Disease-specific pediatric population.- Nonmalignant diseases in children.- 
en.-="" part="" 4:="" disease-specific="" adult="" population.-="" non-malignant="" adults.-="" acute="" myelogenous="" leukemia="" lymphomas-="" parameswaran="" hari.-="" chronic="" leukemias="" and="" myeloproliferative="" neoplasms.-="" immunologic="" reconstitution="" after="" haploidentical="" transplantation.-="" prevention="" treatment="" of="" relapse="" transplant.-="" unique="" complications="" limitations="" future="" prospects="" transplantation

Notă biografică

Stefan Ciurea is Associate Professor in the Department of Stem Cell Transplantation and Cellular Therapy at the University of Texas MD Anderson Cancer Center and leader of the Haploidentical Transplant Program at this institution. Dr. Ciurea received his medical degree from the Gr. T Popa University of Medicine and Pharmacy Iasi, Romania, and had Internal Medicine training at Harrisburg Hospital/PennState University, Fellowship in Hematology/Oncology at the University of Illinois at Chicago and Fellowship in Hematopoietic Stem Cell Transplantation and the University of Texas MD Anderson Cancer Center. He developed a Haploidentical Transplant Program at this institution with the goal to expand safe transplantation to all patients in need. Dr. Ciurea has made significant contributions in this field, primarily in identifying HLA antibodies as major cause of graft failure in mismatched transplantation and improving outcomes for patients with myeloid malignancies treated with hapl
oidentical transplantation, and is principal investigator on multiple clinical trials.

Rupert Handgretinger is Professor of Pediatrics, Chairman of the Department of General Pediatrics and Hematology/Oncology and Medical Director of the Children’s University Hospital Tübingen. He received his medical degree from the Eberhard-Karls-University in Tübingen in 1986 and was trained at the Children's University Hospital Tübingen in General Pediatrics and  Hematology/Oncology. In 2000,  he was appointed as director of the Division of Stem Cell Transplantation at St. Jude Children’s Research Hospital in Memphis, USA, where he served as a full faculty member and Professor of Pediatrics at the University of Tennessee, Memphis, until 2005. He returned to Tübingen in 2005 when he was appointed as Chairman of the Department of General Pediatrics and Hematology/Oncology at the Children's University Hospital Tübingen. His main research interests are cellular im
munotherapeutic approaches to the treatment of children with various forms of cancer in the context of allogeneic stem cell transplantation. He is especially interested in the  establishment of graft engineering techniques to introduce new concepts in haploidentical transplantation and in the elucidation of mechanisms of graft-mediated anti-tumor effects induced by Natural Killer and other effector cells.

Textul de pe ultima copertă

In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant and readily applicable information. Among the areas covered are graft manipulation and methods to control T-cell alloreactivity, the nature of the ideal graft and donor, haploidentical transplantation in pediatric and adult patients with malignant and nonmalignant diseases, immunologic reconstitution following transplantation, complications, and the prevention and treatment of relapse post transplantation. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. The book will provide practical support for hematologists and transplant physicians as they attempt to provide optimal care in this exciting but increasingly complex medical specialty.

Caracteristici

Covers a range of clinically relevant issues in haploidentical transplantation Provides practical support for hematologists and transplant physicians Draws attention to the results of high-impact clinical trials when available Written by renowned experts in the field