This book deals with the general principles, policy instruments, sustainability of supply chain, and business of health-care waste (HCW) management including inputs on exercise in immune health defense against COVID 19. Health-care waste management is very important in any country for protection of environmental and animal and human health. The COVID-19 pandemic, in addition, has augmented this importance to a greater extent. Italy has been successful in curbing the problems related to HCW management during the COVID-19 pandemic at very fast rates from the worst situation, while for a few countries in Asia and Africa, challenges still exist. It is necessary that policy makers, researchers, and implementers gain more knowledge and information on these aspects and improve the strategies and actions. Addressing these issues will reduce the cost of health care as well as resource inefficiency hindering sustainable development goals. This book is of interest and useful to practitioners, capacity builders and policy makers, entrepreneurs, NGOs, and general people, and is a valuable source of reference to the relevant researchers and students in global markets. The book serves as a reading material for undergraduate and graduate students of environmental science, waste management, and medical science. National and international scientists as well as policy makers will also find this to be a useful read.