This book is centered around the development of agile, high-performing healthcare institutions that are well integrated into their environment. The aim is to take advantage of artificial intelligence, optimization and simulation methods to provide solutions to prevent, anticipate, monitor and follow public health developments in order to intervene at the right time, using tools and resources that are both appropriate and effective. The focus is on the people involved - the patients, as well as medical, technical and administrative staff - in an effort to provide an efficient healthcare and working environment that meets safety, quality and productivity requirements. Heathcare Systems has been written by healthcare professionals, researchers in science and technology as well as in the social sciences and humanities from various French-speaking countries. It explores the challenges and opportunities presented by digital technology in our practices, organizations and management techniques.