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Human Molecular Genetics de Tom Strachan

Human Molecular Genetics

Autor Tom Strachan, Andrew Read
en Limba Engleză Paperback – 4 dec 2018
HumanMolecularGeneticshasbeencarefullycraftedoversuccessiveeditionstoprovideanauthoritativeintroductiontothemolecularaspectsofhumangenetics,genomicsandcellbiology.
Maintainingthefeaturesthathavemadepreviouseditionssopopular,thisfiftheditionhasbeencompletelyupdatedinlinewiththelatestdevelopmentsinthefield.Oldertechnologiessuchascloningandhybridizationhavebeenmergedandsummarized,coverageofnewerDNAsequencingtechnologieshasbeenexpanded,andpowerfulnewgeneeditingandsingle-cellgenomicstechnologieshavebeenadded.ThecoverageofGWAS,functionalgenomics,stemcells,anddiseasemodelinghasbeenexpanded.Greaterfocusisgiventoinheritanceandvariationinthecontextofpopulationsandontheroleofepigeneticsingeneregulation.Keyfeatures:
  • Fullyintegratedapproachtothemolecularaspectsofhumangenetics,genomics,andcellbiology
  • Accessibletextissupportedandenhancedthroughoutbysuperbartworkillustratingthekeyconceptsandmechanisms
  • Summaryboxesattheendofeachchapterprovideclearlearningpoints
  • Annotatedfurtherreadinghelpsreadersnavigatethewealthofadditionalinformationinthiscomplexsubjectandprovidesdirectionforfurtherstudy
  • Reorganizedintofivesectionsforimprovedaccesstorelatedtopics
  • Alsonewtothisedition-brandnewchapteronevolutionandanthropologyfromtheauthorsofthehighlyacclaimedHumanEvolutionaryGenetics
Aprovenandpopulartextbookforupper-levelundergraduatesandgraduatestudents,theneweditionofHumanMolecularGeneticsremainsthe'go-to'bookforthosestudyinghumanmoleculargeneticsorgenomicscoursesaroundtheworld.
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Specificații

ISBN-13: 9780815345893
ISBN-10: 0815345895
Pagini: 784
Ilustrații: 496 Line drawings, color; 38 Halftones, color; 136 Tables, color; 535 Illustrations, color
Dimensiuni: 210 x 280 x 40 mm
Greutate: 2.33 kg
Ediția:5th ed
Editura: CRC Press
Colecția Garland Science

Public țintă

Postgraduate, Professional, and Undergraduate

Cuprins

Part 1: Basics of DNA, Chromosomes, Cells, Development and Inheritance.  1. Basic Principles of Nucleic Acid Structure and Gene Expression.  2. Fundamentals of Cells and Chromosomes.  3. Fundamentals of Cell-Cell Interactions and Immune System Biology.  4. Aspects of Early Mammalian Development, Cell Differentiation, and Stem Cells.  5. Patterns of Inheritance. Part 2: Understanding Genomes.  6. Core DNA Technologies: Amplifying DNA, Nucleic Acid Hybridization, and DNA Sequencing.  7. Analyzing the Structure and Expression of Genes and Genomes.  8. Principles of Genetic Manipulation of Mammalian Cells.  9. Uncovering the Architecture and Workings of the Human Genome. 10. Gene Regulation and the Epigenome. Part 3: Genetic Variation between Individuals and Species.  11. An Overview of Human Genetic Variation.  12. Human Population Genetics.  13. Comparative Genomics and Genome Evolution.  14. Human Evolution. Part 4: Human Genetic Disease.  15. Chromosomal Abnormalities and Structural Variants.  16. Molecular Pathology: Connecting Phenotypes to Genotypes.  17. Mapping and Identifying Genes for Monogenic Disorders. 18. Complex Disease: Identifying Susceptibility Factors and Understanding Pathogenesis.  19. Cancer Genetics and Genomics.  Part 5: Applied Human Molecular Genetics.   20. Genetic Testing in Healthcare and the Law.  21. Model Organisms and Modeling Disease.  22. Genetic Approaches to Treating Disease.

Notă biografică

Tom Strachan is Emeritus Professor of Human Molecular Genetics at Newcastle University, Newcastle, UK, and is a Fellow of the Royal Society of Edinburgh and a Fellow of the Academy of Medical Sciences. He was the founding Head of Institute at Newcastle University’s Institute of Human Genetics (now the Institute of Genetic Medicine) and its Scientific Director from 2001 to 2009. Tom’s early research interests were in multigene family evolution and interlocus sequence exchange, notably in the HLA and 21-hydroxylase gene clusters. While pursuing the latter, he became interested in medical genetics. His most recent research has focused on developmental disorders and developmental control genes.
Andrew Read is Emeritus Professor of Human Genetics at the University of Manchester, UK and a Fellow of the Academy of Medical Sciences. Andrew has been particularly concerned with making the benefits of DNA technology available to people with genetic problems. He established one of the first DNA diagnostic laboratories in the UK over 20 years ago (it is now one of two National Genetics Reference Laboratories), and was founder chairman of the British Society for Human Genetics, the main professional body in this area. His own research is on the molecular pathology of various hereditary syndromes, especially hereditary hearing loss.
Drs. Strachan and Read were recipients of the European Society of Human Genetics Education Award

Recenzii

"With every edition, the authors have improved their significant contribution to the field of human molecular genetics teaching. This book's excellent design makes it unique and it provides a wonderful platform for student learning on a
complex subject."
Luis F Escobar, MD., MS.(Peyton Manning Children's Hospital)

Descriere

Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics, genomics and cell biology. Maintaining the features that have made previous editions so popular, this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized, coverage of newer DNA sequencing technologies has been expanded, and powerful new gene editing and single-cell genomics technologies have been added.

The coverage of GWAS, functional genomics, stem cells, and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation. Key features:Fully integrated approach to the molecular aspects of human genetics, genomics, and cell biologyAccessible text is supported and enhanced throughout by superb artwork illustrating the key concepts and mechanismsSummary boxes at the end of each chapter provide clear learning pointsAnnotated further reading helps readers navigate the wealth of additional information in this complex subject and provides direction for further studyReorganized into five sections for improved access to related topicsAlso new to this edition - brand new chapter on evolution and anthropology from the authors of the highly acclaimed Human Evolutionary GeneticsA proven and popular textbook for upper-level undergraduates and graduate students, the new edition of Human Molecular Genetics remains the 'go-to' book for those studying human molecular genetics or genomics courses around the worl