Immuno Systems Biology: A macroscopic approach for immune cell signaling: Systems Biology, cartea 3
Autor Kumar Selvarajooen Limba Engleză Paperback – 23 aug 2016
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Specificații
ISBN-13: 9781493950904
ISBN-10: 1493950908
Pagini: 146
Ilustrații: IX, 146 p. 69 illus., 61 illus. in color.
Dimensiuni: 155 x 235 x 9 mm
Greutate: 0.23 kg
Ediția:Softcover reprint of the original 1st ed. 2013
Editura: Springer
Colecția Springer
Seria Systems Biology
Locul publicării:New York, NY, United States
ISBN-10: 1493950908
Pagini: 146
Ilustrații: IX, 146 p. 69 illus., 61 illus. in color.
Dimensiuni: 155 x 235 x 9 mm
Greutate: 0.23 kg
Ediția:Softcover reprint of the original 1st ed. 2013
Editura: Springer
Colecția Springer
Seria Systems Biology
Locul publicării:New York, NY, United States
Cuprins
Preface.- Systems biology of population cell response.- Perturbation-response approach for biological network analysis.- Basics of the mammalian immune system.- Inferring novel features of the TLR4 pathways.- Signaling Flux Redistribution.- Investigating the TLR3 signaling dynamics.- Understanding TNFR1 signaling dynamics.- TRAIL signaling in cancer.- Stochasticity and variability: insights from single cell dynamics.- Investigating single cell stochasticity in TRAIL signaling.- The distinction between single cell and population dynamics.- Finding chaos in biology.- Concluding remarks.- Index.
Textul de pe ultima copertă
Technological advances of modern biology have generated high volumes of ‘omics’ data. The natural precedence has been to put the complex information together, so that it will lead to spectacular scientific discoveries and medical breakthroughs. In this light, tremendous efforts worldwide are reshaping biological research by integrating with information science. Despite the ‘systems biology’ efforts, for major illnesses, such as proinflammatory diseases and cancer, there is clear clinical evidence that even the most current therapies, at best, control transient response and subdue to the robust adaptability of the disease state. Hence, there is a need for system-levels understanding of bio-complexity.
Kumar Selvarajoo brings attention to fundamental questions governing sophisticated behaviors of the mammalian immune system. To tackle some of the complex issues, the book introduces perturbation-response approach, using the law of physics (mass flow conservation), as a means to interpret the dynamic response of major proinflammatory pathways of the immune and cancer cells. Overall, the book provides an illustrated journey that explains biological cell signaling in simple terms.
Kumar Selvarajoo brings attention to fundamental questions governing sophisticated behaviors of the mammalian immune system. To tackle some of the complex issues, the book introduces perturbation-response approach, using the law of physics (mass flow conservation), as a means to interpret the dynamic response of major proinflammatory pathways of the immune and cancer cells. Overall, the book provides an illustrated journey that explains biological cell signaling in simple terms.
Caracteristici
Immuno systems biology specifically aims to study the host immune system in a more integrated manner Focuses on the dynamical analyses of mammalian innate immune response to bacterial and viral perturbations using computational models based on simple physical rules Deals with interpreting population level immune cell signaling response in wildtype and mutant cells Includes supplementary material: sn.pub/extras