Immunotherapy for Gastrointestinal Cancer
Editat de David Kerr, Rebecca Johnsonen Limba Engleză Paperback – 12 iul 2018
Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application and the key effector cells and mechanisms which might cause tumour rejection. The reverse side of this equation, the genetic and molecular mechanisms which the tumour can use to escape immune control and regulation, is also discussed. Through reviewing the most up-to-date evidence, this volume provides an overview of the important scientific lessons learned from past failure of immunotherapeutics in the clinic and highlights more positive recent data, coupled to practical guidelines for clinical usage.
Written by a team of worldwide experts, this is an indispensable guide for medical oncologists, surgical oncologists, radiation therapists, pharmacists, oncology nurse specialists.
Toate formatele și edițiile | Preț | Express |
---|---|---|
Paperback (1) | 645.24 lei 38-44 zile | |
Springer International Publishing – 12 iul 2018 | 645.24 lei 38-44 zile | |
Hardback (1) | 1018.87 lei 3-5 săpt. | |
Springer International Publishing – 16 ian 2017 | 1018.87 lei 3-5 săpt. |
Preț: 645.24 lei
Preț vechi: 679.19 lei
-5% Nou
Puncte Express: 968
Preț estimativ în valută:
123.53€ • 128.40$ • 102.42£
123.53€ • 128.40$ • 102.42£
Carte tipărită la comandă
Livrare economică 01-07 februarie 25
Preluare comenzi: 021 569.72.76
Specificații
ISBN-13: 9783319827285
ISBN-10: 3319827286
Pagini: 252
Ilustrații: VIII, 252 p. 23 illus. in color.
Dimensiuni: 155 x 235 mm
Ediția:Softcover reprint of the original 1st ed. 2017
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland
ISBN-10: 3319827286
Pagini: 252
Ilustrații: VIII, 252 p. 23 illus. in color.
Dimensiuni: 155 x 235 mm
Ediția:Softcover reprint of the original 1st ed. 2017
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland
Cuprins
Introduction to modern immunology.- Cell based therapy – modified cancer cells.- Vaccines for GI cancer.- Antibody delivery of radioactive ‘warheads’ and cytotoxins.- Antibodies which inhibit specific cell pathways.- PD1 and PD1l immune checkpoint inhibitors.- The Role of the JAK/STAT Signaling Pathway in Immunoregulation of Gastrointestinal Cancers.- Hyper mutated colorectal cancer and neoantigen load.- Antibodies which inhibit specific cell pathways, colorectal cancer.
Notă biografică
David J Kerr CBE MD DSc FRCP(Glas,Lon,Edin) FRCGP FMedSci is Professor of Cancer Medicine, University of Oxford, Adjunct Professor of Medicine, Weill-Cornell College of Medicine and Honorary Professor, University of Xiamen and 2nd Military University, Shanghai. He has a long standing interest in the biology and treatment of colorectal cancer and has contributed many publications to this field. He is former President of the European Society of Medical Oncology and is currently Editor in Chief of the Journal of Global Oncology.
Dr Rebecca Johnson is a junior doctor working at Oxford University Hospitals NHS Foundation Trust. Rebecca holds a Bachelor of Science degree in Genetics and a PhD in DNA double strand break repair. Rebecca was awarded the Irvington Fellowship of the Cancer Research Institute of the United States of America, for work investigating the initiating molecular lesions of common malignancies, this award was tenured at New York University. Following this postdoctoral fellowship, she studied medicine at the University of Birmingham and has recently entered the Core Medical training programme.
Dr Rebecca Johnson is a junior doctor working at Oxford University Hospitals NHS Foundation Trust. Rebecca holds a Bachelor of Science degree in Genetics and a PhD in DNA double strand break repair. Rebecca was awarded the Irvington Fellowship of the Cancer Research Institute of the United States of America, for work investigating the initiating molecular lesions of common malignancies, this award was tenured at New York University. Following this postdoctoral fellowship, she studied medicine at the University of Birmingham and has recently entered the Core Medical training programme.
Textul de pe ultima copertă
This book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy.
Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application and the key effector cells and mechanisms which might cause tumour rejection. The reverse side of this equation, the genetic and molecular mechanisms which the tumour can use to escape immune control and regulation, is also discussed. Through reviewing the most up-to-date evidence, this volume provides an overview of the important scientific lessons learned from past failure of immunotherapeutics in the clinic and highlights more positive recent data, coupled to practical guidelines for clinical usage. Written by a team of worldwide experts, this is an indispensable guide for medical oncologists, surgical oncologists, radiation therapists, pharmacists, oncology nurse specialists.
Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application and the key effector cells and mechanisms which might cause tumour rejection. The reverse side of this equation, the genetic and molecular mechanisms which the tumour can use to escape immune control and regulation, is also discussed. Through reviewing the most up-to-date evidence, this volume provides an overview of the important scientific lessons learned from past failure of immunotherapeutics in the clinic and highlights more positive recent data, coupled to practical guidelines for clinical usage. Written by a team of worldwide experts, this is an indispensable guide for medical oncologists, surgical oncologists, radiation therapists, pharmacists, oncology nurse specialists.
Caracteristici
Explores recent advances in cancer immunotherapy and their application in clinical practice Introduces concepts of modern immunology to the oncology expert Reviews the evidence and scientific lessons learnt from use of immunotherapeutics in the clinic Provides practical guidelines for clinical usage