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Immunotherapy for Gastrointestinal Malignancies: Diagnostics and Therapeutic Advances in GI Malignancies

Editat de Ramakrishna Vadde, Ganji Purnachandra Nagaraju
en Limba Engleză Hardback – feb 2021
 
This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies.
 
The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies. 

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Specificații

ISBN-13: 9789811564864
ISBN-10: 9811564868
Pagini: 251
Ilustrații: XII, 251 p. 34 illus., 27 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.54 kg
Ediția:1st ed. 2020
Editura: Springer Nature Singapore
Colecția Springer
Seria Diagnostics and Therapeutic Advances in GI Malignancies

Locul publicării:Singapore, Singapore

Cuprins

1 Tumor heterogeneity: challenges and perspectives for gastrointestinal cancer therapy.- 2 immune composition of gastrointestinal tract of Gut.- 3 Immunomarkers for detection of GI malignancies.- 4 Immuno-therapeutics of gastrointestinal malignancies.- 5 Immune cell therapy against gastrointestinal tract cancers.- 6 Immune checkpoint inhibitors in gastrointestinal malignancies.- 7 Monoclonal Antibody therapy against gastrointestinal tract cancers.- 8 Therapeutic Vaccines for Gastrointestinal Malignancies.- 9 Immuno-Oncology of Oesophageal Cancer.- 10 Association between IL6 gene polymorphisms and gastric cancer risk: A meta-analysis of case-control studies.- 11 Immuno-oncology of colorectal cancer.- 12 Immune targets in colorectal cancer.- 13 Applications of computational biology in gastrointestinal malignancies. 


Notă biografică

Dr Vadde Ramakrishna is an Assistant Professor at the Department of Biotechnology & Bioinformatics, Yogi Vemana University, India. He obtained his MSc and PhD, both in Biochemistry, from Sri Krishnadevaraya University, Anantapur, India, and subsequently received a DBT CREST Award to pursue advanced training in cancer research at Pennsylvania State University and Colorado State University, USA. He is currently using in vitro, in vivo and in silico models to explore the role of dietary bioactive compounds in both the development and prevention of cancer through a ‘polypharmacology’ approach. He has published over 75 research papers in prominent international journals and has presented more than 40 papers at national and international conferences. He serves as an editorial board member for several international journals, and is an Associate Fellow of Andhra Pradesh Akademi of Sciences.
 
Dr Ganji PurnachandraNagaraju is a faculty member at the Department of Hematology and Medical Oncology, Emory University School of Medicine. Holding a DSc from Berhampur University in Berhampur, India, his research focuses on translational projects concerning gastrointestinal malignancies. He has published over 90 research papers in prominent international journals and has presented more than 50 papers at national and international conferences. Dr Nagaraju is the author and editor of several books and serves as an editorial board member for numerous academic journals. He is an associate member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute, and has received several international awards for his contributions.



Textul de pe ultima copertă

This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies.  
The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies. 


Caracteristici

Examines immunotherapy strategies against GI malignances Reviews strategies including immune checkpoint inhibitors, dendritic cell vaccines, T-cell transfer, and peptide vaccines Describes the cytokines involved in GI malignancies Highlights the role of computational biology in the detection and treatment of GI malignancies