This book covers a variety of topics in the field of mechatronics engineering, with a special focus on innovative control and automation concepts for applications in a wide range of field, including industrial production, medicine and rehabilitation, education and transport. Based on a set of papers presented at the 1^st International Conference “Innovation in Engineering”, ICIE, held in Guimarães, Portugal, on June 28-30, 2021, the chapters report on cutting-edge control algorithms for mobile robots and robot manipulators, innovative industrial monitoring strategies for industrial process, improved production systems for smart manufacturing, and discusses important issues related to user experience, training and education, as well as national developments in the field of mechatronics . This volume, which belongs to a three-volume set, provides engineering researchers and professionals with a timely overview and extensive information on trends and technologies behind the future developments of mechatronics systems in the era of Industry 4.0.