In Mexico, one of the most recent policies aiming to promote new ways of encouraging the generation and application of knowledge has been the impulse to create academic committees in which full-time professors share one or several Innovative Knowledge Generation and Application Research Topics in both disciplinary and multi-disciplinary topics and academic objectives in public higher education institutions, in order to strengthen academic dynamics in collaborative work through the constitution of multidisciplinary teams. This work presents six case studies of collaborative applications involving companies and institutions. The first case study refers to Design and Mold Making for Testing New Paint Pigments. The second is Packaging Optimization for Christmas Tree Ornaments Through Differential Evolution. The third is a Comprehensive Communications Plan for E.J.K. Chemicals. The fourth is Innovation for the Agro-Industrial Sector. The fifth case study is Implementation of a Corporate Financing Project, and the last one is Information Technology Applications: Learning Media Objects for Special Needs Children and Youth at CAM No. 4. This work is presented in collaboration with Universidad Tecnológica de Tlaxcala, Universidad Tecnológica de Tecamachalco, Universidad Tecnológica de Tehuacán, Instituto Tecnológico Superior de la Sierra Norte de Puebla, Instituto Tecnológico Superior de San Martin Texmelucan, Instituto Tecnológico Superior de la Sierra Negra de Ajalpan and Université Clermont Auvergne (France).