Life on The Mississippi begins with a brief history of the river as reported by Europeans and Americans, beginning with the Spanish explorer Hernando de Soto in 1542. It continues with anecdotes of Twain's training as a steamboat pilot, as the 'cub' (apprentice) of an experienced pilot, Horace E. Bixby. He describes, with great affection, the science of navigating the ever-changing Mississippi River in a section that was first published in 1876, entitled "Old Times on the Mississippi."