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Malaria: Genetic and Evolutionary Aspects: Emerging Infectious Diseases of the 21st Century

Editat de Krishna R. Dronamraju, Paolo Arese
en Limba Engleză Hardback – 14 dec 2005
This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called “Malaria Hypothesis”, that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane’s contribution from two directions: (a) it has been suggested that the “Malaria Hypothesis” was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004). Surely, both c- not be right. In fact, the evidence presented in this book clearly indicates that both are wrong. Haldane’s malaria hypothesis has stimulated a great deal of research on the genetic, evolutionary and epidemiological aspects of malaria d- ing the last 50 years. It has opened up a whole new chapter in the study of infectious diseases. It deserves serious consideration. For helpful discussions we thank Lucio Luzzatto, Alberto Piazza, Guido Modiano and David Roberts.
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Specificații

ISBN-13: 9780387282947
ISBN-10: 0387282947
Pagini: 190
Ilustrații: XI, 190 p. 26 illus.
Dimensiuni: 155 x 235 x 13 mm
Greutate: 0.46 kg
Ediția:2006
Editura: Springer
Colecția Springer
Seria Emerging Infectious Diseases of the 21st Century

Locul publicării:New York, NY, United States

Public țintă

Professional/practitioner

Cuprins

J.B.S. Haldane (1892–1964).- Removal of Early Parasite Forms from Circulation as a Mechanism of Resistance Against Malaria in Widespread Red Blood Cell Mutations.- Clinical, Epidemiological, and Genetic Investigations on Thalassemia and Malaria in Italy.- Resistance to Antimalarial Drugs: Parasite and Host Genetic Factors.- Evolutionary Origins of Human Malaria Parasites.- Vector Genetics in Malaria Control.- The Rate of Mutations of Human Genes.- Disease and Evolution.

Recenzii

From the reviews:
"Malaria focuses on genetic and evolutionary insights into a paradise blamed for the death of a child every 30 s worldwide. … Malaria: Genetic and Evolutionary Aspects will benefit a broad range of medical, scientific, and public health professionals. Besides strengthening our understanding of the evolutionary origins of malaria, the text opens new perspectives into infectious diseases." (Richard A. Stein, American Journal of Physical Anthropology, Vol. 133, 2007)

Caracteristici

An edited collection of papers by leading experts on the population genetics and evolutionary biology of malaria Includes supplementary material: sn.pub/extras