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Mechanisms of Disease Pathogenesis in Multiple Sclerosis

Editat de Francisco Javier Quintana
en Limba Engleză Paperback – 13 iun 2024
Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book.

  • Summarizes our current understanding of Multiple Sclerosis
  • Discusses clinical features and available biomarker monitoring
  • Focuses on mechanisms that drive disease pathogenesis
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Specificații

ISBN-13: 9780128238486
ISBN-10: 0128238488
Pagini: 404
Dimensiuni: 152 x 229 mm
Editura: ELSEVIER SCIENCE

Cuprins

1. Multiple Sclerosis, clinical course, open questions and unmet clinical needs
2. Novel Imaging Approaches in Multiple Sclerosis
3. Effect of infections on Multiple Sclerosis
4. T cells in Multiple Sclerosis.
5. B cells in Multiple Sclerosis.
6. Microglia in Multiple Sclerosis.
7. Monocytes in Multiple Sclerosis
8. Antigen Presenting Cells in Multiple Sclerosis.
9. Oligodendrocytes in Multiple Sclerosis.
10. Astrocytes in Multiple Sclerosis.
11. The Blood Brain Barrier in Multiple Sclerosis
12. Microbiome in Multiple Sclerosis.

Recenzii

"…compiles the latest findings in multiple sclerosis (MS) research, organized into chapters that systematically cover the pathogenesis of MS.... By grounding the discussion in the most recent findings from experimental and clinical studies, the book explores processes such as T-cell and B-cell activation, neuroinflammation, and blood-brain barrier disruption. This book offers a comprehensive exploration of the molecular and cellular pathophysiology of MS, focusing on the mechanisms driving the progression and symptomatology of the disease. A standout feature of this book is its focus on linking cellular mechanisms with clinical applications. This connection gives a clear perspective on how pathophysiological processes translate into the physical and cognitive symptoms experienced by patients living with MS.... [A]n essential resource for understanding the intricate mechanisms driving MS pathology." --©Doody’s Review Service, 2024, Sarah M Stuccio, MD (Thomas Jefferson University)