This probing study of melancholy invites readers to view "depression" genealogically through the history of its interpretation. It plumbs interior depths where psychology, theology, philosophy, and literary creation intersect. Therapies proposed for the dark mood have included work, prayer, care of the self, and deepening awareness of its indispensable role in the development of consciousness of oneself and God. Reflecting on these historical responses and cures can prompt a personal exploration, making this a practical manual for self-knowing and self-transcending, a philosophical "guide for the depressed."