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Microdialysis in Drug Development de Markus Müller

Microdialysis in Drug Development: AAPS Advances in the Pharmaceutical Sciences Series, cartea 4

Editat de Markus Müller
en Limba Engleză Paperback – 15 oct 2014
A vast number of diagnostic and therapeutic decisions are based on measuring blood concentrations of molecules, yet most biochemical and pharmacological events actually take place in the tissues. Microdialysis is a key semi-invasive sampling technique to measure in vivo drug penetration to the target site in humans, the method being feasible in virtually every organ. Authored by international experts in this cutting edge field, this book will provide a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development.
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Specificații

ISBN-13: 9781489996213
ISBN-10: 1489996214
Pagini: 352
Ilustrații: XII, 340 p.
Dimensiuni: 155 x 235 x 18 mm
Greutate: 0.49 kg
Ediția:2013
Editura: Springer
Colecția Springer
Seria AAPS Advances in the Pharmaceutical Sciences Series

Locul publicării:New York, NY, United States

Public țintă

Professional/practitioner

Cuprins

Introduction to the Microdialysis Technology.- Recovery and Calibration Techniques: Toward Quantitative Microdialysis.- Analytical Considerations for Microdialysis Sampling.- Regulatory Aspects of Microdialysis: A United States Food & Drug Administration Perspective.- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations.- Microdialysis in Antibiotic Research.- Skin and Transdermal Drug Delivery: Advantages and Challenges.- Translational Approaches For Predicting CNS Drug Effects Using Microdialysis.- Extracellular Amyloid-β Protein Dynamics in Alzheimer's Disease.- Microdialysis in Pain Research.- Microdialysis in Ocular Drug Development.- Microdialysis in Metabolic Research.- High Molecular Weight Targets and Treatments Using Microdialysis.- Complementary Techniques – Positron Emission Tomography.- Open Flow Microperfusion: An Alternative Method to Microdialysis?.- Microdialysis in Internal Organs and Tumors.

Notă biografică

Prof. Markus Müller, MD is Head of the Department of Clinical Pharmacology at the Medical University of Vienna in Austria. He is specialized in Internal Medicine and Clinical Pharmacology and is an international expert in clinical research. He has published over 80 articles on the use and methodology of microdialysis in clinical drug development.

Textul de pe ultima copertă

In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.

Caracteristici

Authored by international experts Provides a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development Describes cutting edge field Includes supplementary material: sn.pub/extras