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MicroRNAs in malignant tumors of the skin: First steps of tiny players in the skin to a new world of genomic medicine de Michael Sand

MicroRNAs in malignant tumors of the skin: First steps of tiny players in the skin to a new world of genomic medicine

Autor Michael Sand
en Limba Engleză Hardback – 9 iun 2016
Michael Sand gives the reader an overview ofcurrent techniques in expression profiling of miRNAs and their maturationmachinery in the skin. This book is a postdoctoral thesis on miRNAs incutaneous malignant melanoma and non-melanoma skin cancer with a focus on themiRNA processing machinery and miRNA expression profiling. The researchpresented in this book was performed in the Dermatologic Surgery Section at theDepartment of Dermatology, Venereology and Allergology of the Ruhr-UniversityBochum, Germany and gives the reader an overview of current techniques inexpression profiling of miRNAs and their maturation machinery in the skin.
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Specificații

ISBN-13: 9783658127930
ISBN-10: 3658127937
Pagini: 246
Ilustrații: XI, 245 p. 1 illus. in color.
Dimensiuni: 148 x 210 x 22 mm
Greutate: 0.57 kg
Ediția:1st ed. 2016
Editura: Springer Fachmedien Wiesbaden
Colecția Springer
Locul publicării:Wiesbaden, Germany

Cuprins

Introduction.- Objectives of this work.- Summary and discussion of this work.- Closing remarks.- Paper 1: Expression levels of the microRNA processing enzymes Drosha and Dicer in epithelial skin cancer.- Paper 2: Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA- induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1 and TARBP2 in epithelial skin cancer.- Paper 3: Expression of microRNAs in basal cell carcinoma.- Paper 4: Microarray analysis of microRNA expression in cutaneous squamous cell carcinoma.- Paper 5: The miRNA machinery in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases and benign melanocytic nevi.- Paper 6: Immunohistochemical expression patterns of the microRNA-processing enzyme Dicer in cutaneous malignant melanomas, benign melanocytic nevi and dysplastic melanocytic nevi.- Paper 7: Comparative microarray analysis of microRNA expression profiles in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases and benign melanocytic nevi.- Paper 8: MicroRNAs and the skin: tiny players in the body’s largest organ.- Paper 9: microRNA in non-melanoma skin cancer.

Notă biografică

Michael Sand, MD studied medicine at the Ruhr-University of Bochum/ Germany, Harvard Medical School Boston and the University of California, SanDiego (UCSD). After board certification in Dermatology, Venereology andEmergency Medicine at the Ruhr-University Bochum / Germany he and his teamstarted to investigate the role of microRNA in the skin. He is currently anattending physician in the Department of Plastic Surgery, Catholic Clinics ofthe Ruhr Peninsula, Essen, Germany with a clinical focus on surgical therapy ofskin cancer and a research focus on the role of microRNAs in malignant skintumors.

Textul de pe ultima copertă

Michael Sand gives the reader an overview ofcurrent techniques in expression profiling of miRNAs and their maturationmachinery in the skin. This book is a postdoctoral thesis on miRNAs incutaneous malignant melanoma and non-melanoma skin cancer with a focus on themiRNA processing machinery and miRNA expression profiling. The researchpresented in this book was performed in the Dermatologic Surgery Section at theDepartment of Dermatology, Venereology and Allergology of the Ruhr-UniversityBochum, Germany and gives the reader an overview of current techniques inexpression profiling of miRNAs and their maturation machinery in the skin.
Contents
  • MicroRNAS
  • Basal cell carcinoma
  • Cutaneous squamous cell carcinoma
  • Cutaneous malignant melanoma
Target Groups
  • Researchers and students in the field ofmedicine, dermatology, molecular biology, pathology
  • Dermatologist and pathologist
About the Author
Michael Sand, MD studied medicine at the Ruhr-University of Bochum/ Germany, Harvard Medical School Boston and the University of California, SanDiego (UCSD). After board certification in Dermatology, Venereology andEmergency Medicine at the Ruhr-University Bochum / Germany he and his teamstarted to investigate the role of microRNA in the skin. He is currently anattending physician in the Department of Plastic Surgery, Catholic Clinics ofthe Ruhr Peninsula, Essen, Germany with a clinical focus on surgical therapy ofskin cancer and a research focus on the role of microRNAs in malignant skintumors.

Caracteristici

in the field of medical sciences