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Mitochondria and Cell Death de David M. Hockenbery

Mitochondria and Cell Death: Cell Death in Biology and Diseases

Editat de David M. Hockenbery
en Limba Engleză Hardback – 4 iul 2016
This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material.
 
Mitochondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology,as well as those interested in the study of mitochondria and cell biology.


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Specificații

ISBN-13: 9781493936106
ISBN-10: 1493936107
Pagini: 286
Ilustrații: XIV, 232 p. 26 illus., 23 illus. in color.
Dimensiuni: 155 x 235 x 16 mm
Greutate: 0.53 kg
Ediția:1st ed. 2016
Editura: Springer
Colecția Humana
Seria Cell Death in Biology and Diseases

Locul publicării:New York, NY, United States

Public țintă

Research

Cuprins

Preface.- 1.Lethal and non-lethal functions of the permeability transition pore.- 2.Mitochondrial Calcium and Ischemia-Reperfusion Injury in
Heart.- 3.Mislocalization of mitochondrial intermembrane space proteins.- 4.Bcl-2 protein interplay on the outer mitochondrial membrane.- 5.Remodeling of Mitochondria in Apoptosis.- 6.Physiologic and Pathologic Functions of Mitochondrial ROS.- 7.Mitochondrial Mutagenesis in Cancer.- 8.Mitochondrial UPR in cancer.- 9.Mitochondrial signaling.- 10.Mitochondria and antiviral immunity.- 11.Mitochondrial permeabilization from lethality to vitality.- Index.




Notă biografică

David M. Hockenbery, MD is Professor, Member & Head of the Gastroenterology & Hepatology Section of the Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance. He is also a Mentor in the Seattle Children’s/UW/Hutchinson Center Pediatric Hematology-Oncology Fellowship Program. He received his M.D. from Washington University in St. Louis, completed his Residency in Medicine at Johns Hopkins and also completed two Fellowships, in Gastroenterology and Molecular Oncology, at Washington University. Dr. Hockenbery’s current research interests include the bcl-2 oncogene and its role in apoptosis, mitochondrial biology and bioenergetic metabolism, utilizing cell culture, transgenic mouse and protein biochemistry approaches for identification of cancer-selective metabolic pathways and discovery of small molecule inhibitors targeting these pathways.

Textul de pe ultima copertă

This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material.
 
Mitochondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology,as well as those interested in the study of mitochondria and cell biology.

Caracteristici

Examines the role of mitochondria in cell death in one comprehensive volume Discusses current understandings of the underlying mechanisms or cell death Emphasizes the importance of mitochondrial dysfunction in pathogenesis of clinical diseases to bench-to-bedside investigations