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Mitochondria: The Anti- cancer Target for the Third Millennium de Jiri Neuzil

Mitochondria: The Anti- cancer Target for the Third Millennium

Editat de Jiri Neuzil, Shazib Pervaiz, Simone Fulda
en Limba Engleză Hardback – 12 iun 2014
This book will be focused on mitochondria as very promising targets for anti-cancer drugs, yet to be fully exploited. It will contain chapters focused on aspects of basic research as well as on clinical relevance, which will be written by specialists in the field. That the role of mitochondria in human pathologies goes beyond the neoplastic diseases will be documented by a chapter of the role of mitochondria in Friedreich's ataxia.
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Specificații

ISBN-13: 9789401789837
ISBN-10: 9401789835
Pagini: 382
Ilustrații: VIII, 382 p. 45 illus., 41 illus. in color.
Dimensiuni: 155 x 235 x 22 mm
Greutate: 0.89 kg
Ediția:2014
Editura: SPRINGER NETHERLANDS
Colecția Springer
Locul publicării:Dordrecht, Netherlands

Public țintă

Research

Cuprins

Preface.- Mitochondrion: A novel center for cancer cell signalling.- Exploiting BH3 mimetics for cancer therapy.- Regulation of mitochondrial function by MicroRNA.- Mitochondrial complex II as a target for anti-cancer drugs.- Exploiting celecoxib in cancer therapy.- Activation of mitochondria-driven pathways by artemisinin and its derivatives.- Vitamin E analogues as prototypic mitochondria-targeting anti-cancer agents.- Targeting mitochondria of cancer cells: Mechanism and compounds.- Targets and strategies for the mitochondrial assault on cancer.- Emerging anti-cancer targets in mitochondria.- Relevance of mitochondrial functions and plasticity in tumor biology.- Crosstalk between p53 and mitochondrial metabolism.- Progression of cardiomyopathy in Friedreich’s ataxia, a mitochondrial disease.- Index.

Textul de pe ultima copertă

Mitochondria: The anti-cancer target for the third millennium is a collection of up-to-date contributions investigating the role of these organelles in human pathology, in particular cancer.
Written by experts in the area of mitochondrial research, this book covers topics ranging from the basic science of the role of mitochondria in cellular homeostasis to more focused topics on the interaction with drugs, emerging targets in pathology and platforms for the development of novel drugs.
The book will appeal to researchers interested in the role of mitochondria in pathology and in the latest discoveries in this area of research.

Caracteristici

Examines the importance of mitochondria as a potential molecular target for the treatment of a variety of human pathologies, in particular cancer Covers the basics as well as more focused topics, such as interaction with drugs, emerging targets in pathology and platforms for the development of novel drugs Features chapters written by experts in the area of mitochondrial research Includes supplementary material: sn.pub/extras