Abstract: Development of statistical experimental designs and models for experiments with mixtures (formulations) when response variables depend on (i) the relative proportions of the mixture components and the total amount of the mixture, (ii) the amounts of mixture components, or (iii) component-wise proportions. Dissertation Discovery Company and University of Florida are dedicated to making scholarly works more discoverable and accessible throughout the world. This dissertation, "Models and Designs for Generalizations of Mixture Experiments Where the Response Depends on the Total Amount" by Gregory Frank Piepel, was obtained from University of Florida and is being sold with permission from the author. A digital copy of this work may also be found in the university's institutional repository, IR@UF. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation.