Molecular Aspects of Oxidative Drug Metabolizing Enzymes: Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health: Nato ASI Subseries H:, cartea 90
Editat de Emel Arinc, John B. Schenkman, Ernest Hodgsonen Limba Engleză Paperback – 13 dec 2011
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Specificații
ISBN-13: 9783642795305
ISBN-10: 3642795307
Pagini: 636
Ilustrații: IX, 614 p. 10 illus.
Dimensiuni: 155 x 235 x 33 mm
Greutate: 0.88 kg
Ediția:Softcover reprint of the original 1st ed. 1995
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Nato ASI Subseries H:
Locul publicării:Berlin, Heidelberg, Germany
ISBN-10: 3642795307
Pagini: 636
Ilustrații: IX, 614 p. 10 illus.
Dimensiuni: 155 x 235 x 33 mm
Greutate: 0.88 kg
Ediția:Softcover reprint of the original 1st ed. 1995
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Nato ASI Subseries H:
Locul publicării:Berlin, Heidelberg, Germany
Public țintă
ResearchCuprins
to Cytochrome P450.- General Aspects of NADPH Cytochrome P450 Reductase and Cytochrome b5.- Interaction Between Cytochrome P450 and Reductase.- Molecular Biology of Cytochrome P450: Evolution, Structure and Regulation.- The Role of Nuclear Receptors in the Regulation of P450s and Other Genes by Peroxisome Proliferators.- Mapping Determinants of the Substrate Specificities of P450s by Site-Directed Mutagenesis.- Diversity and Regulation of Cytochromes P450 in Aquatic Species.- Cytochrome P450 Expression in Rainbow Trout: An Overview.- Molecular Aspects of Cytochrome P450 2E1 and Its Roles in Chemical Toxicity.- Problems Associated with Assessment of the Contribution of Individual Forms of Cytochrome P450 to the Metabolism of Xenobiotics.- Emergence of the Flavin-Containing Monooxygenase Gene Family: Molecular Biology, Structure, and Function.- Flavin-Containing Monooxygenases: Substrate Specificity and Complex Metabolic Pathways.- Developmental Regulation of Biotransformation of Drugs and Other Xenobiotics.- Modulation of Xenobiotic Metabolism and Toxicity by Dietary Chemical.- Mechanisms of Mutagenicity and Tumour Formation.- Genotoxicity Assays.- Use of Mechanistic Information for Adequate Metabolic Design of Genotoxicity Studies and Toxicological Interactions of Drugs and Environmental Chemicals.- Significance of Posttranslational Modification of Drug Metabolizing Enzymes by Phosphorylation for the Control of Carcinogenic Metabolites.- The Construction of Cell Cultures Genetically Engineered for Metabolic Competence towards Xenobiotics.- In Vitro Systems as Analytical Tools for Understanding and Predicting Drug Metabolism In Vivo.- The Role of Oxidative Enzymes in the Metabolism and Toxicity of Pesticides.- Metabolism of Xenobiotic Proestrogens and Estrogens by Cytochrome P450.- Metabolism of Antiestrogenic Anti-Cancer Agents by Cytochrome P450 and Flavin-Containing Monooxygenases. Mechanism of Action Involving Metabolites.- Therapeutic Agents and Cytochrome P450.- Drug Metabolism, Lipid Peroxidation and Glutathione.- Health Environment of Altai Territory and Monooxygenase and Conjugating Activities in Placentae of Newborn.- Monooxygenase Measurements as Indicators of Pollution in the Field.- Biochemical and Genotoxicological Monitoring of Ecosystems with Special Reference to Lake Baikal and Northern Black Sea.- Relating Biochemical Responses to “Higher Order” Effects.- List of Invited Contributors.