Molecular Genetics and Therapy of Leukemia de Emil J. Freireich

Molecular Genetics and Therapy of Leukemia: Cancer Treatment and Research, cartea 84

Emil J. Freireich

Hagop Kantarjian

Leukemia is a malignant disease which continues to play a cutting edge role in the discovery of basic knowledge about the malignant process and about the potential for controlling these malignant diseases. This title covers such topics as chromosome 16, chromosome 5, the BCL-2 gene, 11q23 breakpoint leukemias, and hematopoietic stem cells.

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Cuprins

1. Molecular Genetics of Inversion 16 Leukemia: Implications for Leukemogenesis.- 2. Deletion of Chromosome 5 (5q-) in Leukemia: Current Knowledge.- 3. Bcl-2 Family Proteins and the Regulation of Programmed Cell Death in Leukemia and Lymphoma.- 4. MLL Fusion Genes in the 11q23 Acute Leukemias.- 5. The c-myb Protooncogene: A Novel Target for Human Gene Therapy.- 6. The Role of p53 in Malignancy.- 7. Primitive Hematopoietic Stem and Progenitor Cells in Human Umbilical Cord Blood: An Alternative Source of Transplantable Cells.- 8. Detection of Minimal Residual Disease in ALL: Biology, Methods, and Applications.- 9. Interleukin-6: Biologic Properties and Role in Lymphoproliferative Disorders.- 10. Autologous Bone Marrow Transplantation for Leukemia and Lymphoma.- 11. Retinoblastoma Gene in Malignancy.- 12. Treatment of Relapse After Allogeneic Bone Marrow Transplantation.- 13. Acute Lymphocytic Leukemia: A Comprehensive Review with Emphasis on Biology and Therapy.