Molecular Mechanisms of Synaptogenesis
Editat de Alexander Dityatev, Alaa El-Husseinien Limba Engleză Hardback – 15 aug 2006
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Specificații
ISBN-13: 9780387325606
ISBN-10: 0387325603
Pagini: 497
Ilustrații: XXVI, 497 p. 102 illus., 43 illus. in color.
Dimensiuni: 155 x 235 x 29 mm
Greutate: 0.9 kg
Ediția:2006
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States
ISBN-10: 0387325603
Pagini: 497
Ilustrații: XXVI, 497 p. 102 illus., 43 illus. in color.
Dimensiuni: 155 x 235 x 29 mm
Greutate: 0.9 kg
Ediția:2006
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States
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Public țintă
ResearchDescriere
Some of the molecules critical for building neuronal contacts have been shown to be affected in psychiatric disorders such as autism and mental retardation. Also, a reduction in synapse number in specific brain regions has been found in patients with brain disorders. Thus, imbalance in synaptic contact formation may result in the formation of abnormal neuronal circuits and the aberrant behavior manifested in these brain diseases. Recent findings also suggest that fine tuning of neuronal circuits rather than a major loss of neurons may be the cause of some of these brain disorders. In certain cases, loss of neurons could be a secondary event reflecting problems in improper neuronal communication.
Cuprins
Synaptogenesis: When Long-Distance Relations Become Intimate.- Synaptogenesis: When Long-Distance Relations Become Intimate.- Experimental Models of Synaptogenesis.- The Formation of the Vertebrate Neuromuscular Junction: Roles for the Extracellular Matrix in Synaptogenesis.- Synapse Formation between Identified Molluscan Neurons: A Model System Approach.- Development of the Drosophila and C. Elegans Neuromuscular Junctions.- Mechanisms That Regulate Neuronal Protein Clustering at the Synapse.- Roles of Cell Adhesion and Secreted Molecules in Synaptic Differentiation.- Cadherin-Mediated Adhesion and Signaling During Vertebrate Central Synapse Formation.- Synaptic Functions of the Neural Cell Adhesion Molecule, NCAM.- Role of Neuroligin Binding to Neurexins in Synaptic Organization.- SynCAM in Formation and Function of Synaptic Specializations.- Protocadherins and Synapse Development.- Ephrins and Eph Receptors in Spinogenesis and Synaptic Plasticity.- Extracellular Matrix Molecules and Formation of CNS Synapses.- Role of Neurotrophins in the Formation and Maintenance of Synapses.- Transport of Synaptic Proteins.- Motor-Cargo Interactions Involved in Transport of Synaptic Proteins.- Postsynaptic Transport Packets.- Lateral Diffusion of Excitatory Neurotransmitter Receptors During Synaptogenesis.- Synaptic Cytoskeleton and Morphogenic Signaling.- Assembly of Presynaptic Active Zones.- Assembly of Postsynaptic Protein Complexes in Glutamatergic Synapses.- Regulation of Dendritic Spine Morphology and Synaptic Function By Scaffolding Proteins.- Composition and Assembly of Gabaergic Postsynaptic Specializations.- Role of Synaptogenesis in Morphologic Stabilization of Developing Dendrites.- Protein Kinases and Synaptogenesis.- Signaling from Synapse to Nucleus and Back.- Synaptic Plasticity in Learning and Memory.- Structural Synaptic Correlates of Learning and Memory.- Intracellular Trafficking of AMPA-Type Glutamate Receptors.- Learning-Induced Changes in Sensory Synaptic Transmission.- Synaptogenesis and Brain Disorders.- Relevance of Presynaptic Proteins to Neuropsychiatric Disorders.- Synaptic Abnormalities and Candidate Genes in Autism.- Synaptic Pathology in Depression.- Synaptic Pathology in Dementia.- A Fragile Synapse: Changes at the Synapse in Fragile X Syndrome.- Synaptic Abnormalities Associated with Huntington’s Disease.- Interference Peptides: A Novel Therapeutic Approach Targeting Synaptic Plasticity in Drug Addiction.
Recenzii
From the reviews:
"This volume provides a comprehensive overview and perspectives on the interplay between development, maturity, and disease that is valuable to the newcomer and expert alike. One strength of this volume is that it highlights the breadth of the many experimental systems and approaches that are used to study normal development as well as synaptic defects associated with human diseases. … This volume provides an excellent resource to both established investigators and newcomers to the field." (Ethan G. Hughes and Rita J. Balice-Gordon, Neuron, Vol. 53, 2007)
"This volume provides a comprehensive overview and perspectives on the interplay between development, maturity, and disease that is valuable to the newcomer and expert alike. One strength of this volume is that it highlights the breadth of the many experimental systems and approaches that are used to study normal development as well as synaptic defects associated with human diseases. … This volume provides an excellent resource to both established investigators and newcomers to the field." (Ethan G. Hughes and Rita J. Balice-Gordon, Neuron, Vol. 53, 2007)
Textul de pe ultima copertă
Molecular Mechanisms of Synaptogenesis is a compilation of recent exciting findings that summarizes the ever-expanding knowledge of how neuronal contacts develop in the normal brain and how their functions are affected in mental disorders.
In the last decade, advances in molecular and cellular biology, combined with the development of sophisticated fluorescence microscopy tools to visualize synapses in live neurons, have revealed many intriguing and unexpected findings regarding the dynamics of synapse formation. Studies by a number of researchers have identified several critical protein components of synapses and shown the time course of their arrival at the synapse. Several molecules serve to hold the synaptic contacts between nerve cells and regulate their function.
Imbalance in synaptic contact formation and function has been linked to psychiatric disorders such as schizophrenia, autism and mental retardation. The recent advances in basic research, summarized in Molecular Mechanisms of Synaptogenesis, may lay the necessary scientific groundwork to develop treatments targeting synaptogenesis, allowing us to improve the lives of people affected by brain disorders. This book will be an invaluable resource for neurobiologists taking their first steps in the expanding and exciting field of synaptogenesis.
In the last decade, advances in molecular and cellular biology, combined with the development of sophisticated fluorescence microscopy tools to visualize synapses in live neurons, have revealed many intriguing and unexpected findings regarding the dynamics of synapse formation. Studies by a number of researchers have identified several critical protein components of synapses and shown the time course of their arrival at the synapse. Several molecules serve to hold the synaptic contacts between nerve cells and regulate their function.
Imbalance in synaptic contact formation and function has been linked to psychiatric disorders such as schizophrenia, autism and mental retardation. The recent advances in basic research, summarized in Molecular Mechanisms of Synaptogenesis, may lay the necessary scientific groundwork to develop treatments targeting synaptogenesis, allowing us to improve the lives of people affected by brain disorders. This book will be an invaluable resource for neurobiologists taking their first steps in the expanding and exciting field of synaptogenesis.
Caracteristici
Provides a new compilation of information that link changes in the basic structure of synapses and brain diseases, which have not been done yet
Shows that specific secreted proteins, and short peptide mimicking the function of neural cell adhesion molecules can significantly enhance the formation of synapses in the brain
Describes recent advances in research that lay necessary scientific groundwork to develop pharmacological treatments targeting synaptogenesis and allowing us to improve the lives of people affected by brain disorders
Includes supplementary material: sn.pub/extras
Shows that specific secreted proteins, and short peptide mimicking the function of neural cell adhesion molecules can significantly enhance the formation of synapses in the brain
Describes recent advances in research that lay necessary scientific groundwork to develop pharmacological treatments targeting synaptogenesis and allowing us to improve the lives of people affected by brain disorders
Includes supplementary material: sn.pub/extras