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Molecular Mechanisms of Werner’s Syndrome

Autor Michel Lebel
en Limba Engleză Paperback – 6 noi 2012
During our short time on earth, we all undergo the highly complex process of aging, and with it, we experience the many physiological symptoms. Studies of premature aging have produced a great deal of information that gives some aspects of aging a better understanding. This book explores Werner's syndrome. To some, Werner's syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.
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Specificații

ISBN-13: 9781461347668
ISBN-10: 1461347661
Pagini: 168
Ilustrații: X, 156 p.
Dimensiuni: 156 x 234 x 9 mm
Greutate: 0.25 kg
Ediția:Softcover reprint of the original 1st ed. 2004
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States

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Cuprins

1. Clinical Aspects of Werner’s Syndrome: Its Natural History and the Genetics of the Disease.- 2. Biochemical Roles of RecQ Helicases.- 3. Biochemical Characterization of the Werner Syndrome DNA Helicase-Exonuclease.- 4. Proteins That Interact with the Werner Syndrome Gene Product.- 5. Sensitivity of Werner’s Syndrome Cells to DNA Damaging Agents: Insights into the Biological Functions of the Werner Protein.- 6. Yeast RecQHelicases: Clues to DNA Repair, Genome Stability and Aging.- 7. Potential Function of the Werner’s Syndrome Homologue in the African Clawed Frog and the Mouse.- 8. Proposed Biological Functions for the Werner Syndrome Protein in DNA Metabolism.- Replicative Senescence, Telomeres and Werner’s Syndrome.