Every year since 2002, over the third weekend of September, the town of Point Pleasant, West Virginia holds its Mothman Festival. But starting back in November 1966, locals reported dozens of disturbing sightings of a winged man near the Silver Bridge over the Ohio River. A little less than a year later, the Silver Bridge collapsed due to undetected structural defects right at the evening rush hour. Forty-six people lost their lives and nine more were injured.

Mothman's Vengeance offers a new perspective on an ancient Shawnee curse and ongoing mystery. When New York Detective Richard Cooper is found brutally murdered, Point Pleasant police search diligently for clues but come up empty-handed. As Richard's only son Michael presses the police, he begins to remember childhood nightmares of a red-eyed spectre. Then he learns his estranged mother was killed by a hit and run driver. As strange happenings and disturbing phone calls mount around Michael and his young family, the mystery deepens. Safe only within the walls of his ancestral home, Michael must find the clue that will release the curse that has killed generations of his forebears.