This bookconstitutes the thoroughly refereed post-conference proceedings of the 16thInternational Workshop on Multi-Agent-Based Simulation, MABS 2015, held inIstanbul, Turkey, in May 2015. The workshop was held in conjunction with the14th International Conference on Autonomous Agents and Multi-agent Systems,AAMAS 2015.
The 12revised full papers included in this volume ware carefully selected from 22submissions. The papers focus on theinfluence of social sciences and multi-agent systems, with a strongapplication/empirical vein, and its emphasis is stressed on exploratory agentbased simulation as a principled way of undertaking scientific research in thesocial sciences and using social theories as an inspiration to new frameworks  and developments in multi-agent systems.