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Multiple Action-Based Design Approaches to Antibacterials de John Bremner

Multiple Action-Based Design Approaches to Antibacterials

Autor John Bremner
en Limba Engleză Paperback – 7 apr 2022
This book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is interdisciplinary, and it provides greater understanding of the complex interplay of factors involved in the medicinal chemistry design and laboratory development of multiply active antibacterials. The scope of the book appeals to readers who are researching in the field of antibacterials using the approach of medicinal chemistry design and drug development. 

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Specificații

ISBN-13: 9789811610011
ISBN-10: 9811610010
Ilustrații: XIII, 193 p. 103 illus., 10 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.3 kg
Ediția:1st ed. 2021
Editura: Springer Nature Singapore
Colecția Springer
Locul publicării:Singapore, Singapore

Cuprins

Introduction to Antibacterials.- Antibacterial Combinations.- Single Molecule Non-cleavable Multiply Active Antibacterials.- Design Principles and Development of  Multiply Active Pro-drug Antibacterials.- Future Possibilities.

Notă biografică

John Bremner was born in Perth, Western Australia and after completion of his undergraduate studies at the University of Western Australia he undertook a PhD at the Australian National University. After a further year at Harvard University as a Research Fellow he returned to Australia to take up a Lectureship in Chemistry at the University of Tasmania. Later, on sabbatical leave, he completed a Diploma in Chemical Pharmacology at the University of Edinburgh. In 1991 he was appointed as Professor of Organic Chemistry at the University of Wollongong in NSW, Australia. He retired in 2007 and is now an Emeritus Professor of the University of Wollongong. He is a Fellow of The Royal Australian Chemical Institute and received a Distinguished Fellow Award of the RACI in 2011. In 2001 he received the Adrien Albert Award in medicinal chemistry. He is also a Fellow of the Royal Society of Chemistry.

Textul de pe ultima copertă

This book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is interdisciplinary, and it provides greater understanding of the complex interplay of factors involved in the medicinal chemistry design and laboratory development of multiply active antibacterials. The scope of the book appeals to readers who are researching in the field of antibacterials using the approach of medicinal chemistry design and drug development. 

Caracteristici

Provides readers with suggestions for further research using specific examples as starting points in the design process – for example, the antibacterial alkaloid berberine Includes a comparative section relating combinations, hybrids, and pro-drug features which will assist further developments in the field Suggests for pathways to refine some illustrative hypothetical molecular examples in order to bring them closer to experimental testing