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Myelin Basic Protein

Autor Joan M. Boggs
en Limba Engleză Hardback – 24 noi 2008
The compact myelin sheath formed around nerve axons speeds up nerve conduction and also nurtures the axon. Destruction of this sheath in demyelinating diseases such as multiple sclerosis (MS) results in nerve conduction failure and neurodegeneration. Myelin basic protein (MBP) is the second most abundant protein of central nervous system (CNS) myelin (after the proteolipid protein), representing about 30 % of the total myelin protein and about 10 % of myelin by weight. It is also present in peripheral nervous system (PNS) myelin but as a lower percentage of the total protein. This book addresses the issue of Myelin and the way it binds to negatively-charged lipids on the cytosolic surfaces of the processes and is responsible for adhesion of these surfaces of myelin in the CNS, thus forming the major dense line observed by electron microscopy.
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Specificații

ISBN-13: 9781604566994
ISBN-10: 160456699X
Pagini: 249
Ilustrații: colour & b/w illus
Dimensiuni: 189 x 262 x 23 mm
Greutate: 0.77 kg
Editura: Nova Science Publishers Inc

Cuprins

Preface; The Properties and Functions of the Golli Myelin Basic Proteins ; Posttranslational Modifications of Myelin Basic Proteins; Deimination of MBP by PAD enzymes, and Their Role in Multiple Sclerosis ; MBP-Mediated Immunopathogenesis in Multiple Sclerosis and EAE; A Structural Perspective of Peptides from Myelin Basic Protein; Interactions of the 18.5 kDa Myelin Basic Protein (MBP) with Lipid Bilayers -- Studies by Electron Paramagnetic Resonance (EPR) Spectroscopy and Implications for Generation of Autoimmunity in Multiple Sclerosis; Insights on the Interaction of MBP with Microtubules; Myelin Basic Protein Interactions with Actin and Tubulin in vitro -- Binding, Assembly, and Regulation ; Molecular Modelling of the Interaction of Myelin Basic Protein (MBP) Peptides with Signaling Proteins and Effects of Post-Translational Modifications ; Structure and Dynamics of the Myelin Basic Protein (MBP) Family by Solution and Solid-State NMR; Index.