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Nanoparticles for Brain Drug Delivery

Editat de Carla Vitorino, Andreia Jorge, Alberto A.C.C. Pais
en Limba Engleză Hardback – 16 mar 2021
In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. 
The book encompasses general aspects pertaining to fundamental development, including tripartite in silico–in vitro–in vivo approaches. It also covers a diversity of nanomedicines applied in treatment and/or diagnosis and monitoring of CNS disorders. Aspects concerning their translation from the bench to clinical practice are also seamlessly discussed. 
This book will inspire readers to discover possible approaches to holistically delivering drugs into the brain. Edited by Carla Vitorino, Andreia Jorge and Alberto Pais, this book will appeal to anyone involved in nanomedicine, pharmaceutics, neurological and cancer therapies, drug delivery research and computational and regulatory sciences.
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Specificații

ISBN-13: 9789814877312
ISBN-10: 981487731X
Pagini: 518
Ilustrații: 1 Tables, color; 16 Tables, black and white; 17 Illustrations, color; 29 Illustrations, black and white
Dimensiuni: 152 x 229 x 30 mm
Greutate: 1.12 kg
Ediția:1
Editura: Jenny Stanford Publishing
Colecția Jenny Stanford Publishing

Public țintă

Academic and Professional Practice & Development

Cuprins

Part 1: Fundamentals  1. Recent Trends in Nanotechnology for Brain Delivery: A Brief Outlook  2. Understanding Brain Delivery  3. Novel Routes to Accessing the Brain: Intranasal Administration  Part 2: Nanomedicines  4. Organic Nanocarriers for Brain Drug Delivery  5. Magnetic and Plasmonic Nanoparticles for Brain Drug Delivery Ana Luísa Daniel-da-Silva  6. Hybrid Nanosystems  7. Drug Nanocrystals  8. Lipid Nanocarriers for Oligonucleotide Delivery to the Brain  9. Carriers for Nucleic Acid Delivery to the Brain  10. Advances in Nanotheranostics with Plasmonic and Magnetic Nanoparticles  Part 3: Development and Translation  11. Quality by Design for Nanocarriers  12. Recent in vitro Models for the Blood–Brain Barrier  13. Current in vivo Models for Brain Disorders  14. Modeling and Simulation of Nanosystems for Delivering Drugs to the Brain  15. Translational Challenges

Notă biografică

Carla Vitorino is invited assistant professor at the Faculty of Pharmacy of the University of Coimbra, Portugal (2014–present). She graduated in pharmaceutical sciences in 2007 and obtained her PhD in pharmaceutics in 2013 from the University of Coimbra. She has been working on the application of nanotechnology in drug permeation enhancement strategies for transdermal, oral and drug delivery systems for brain targeting and has published several scientific papers in peer-reviewed, high-impact journals, bringing together her vast experience in pharmaceutical technology, especially in the areas of nanotechnology and regulatory science. Her main research interests are nanotechnology, controlled release and the development of new drug delivery systems with a quality-by-design perspective. 
Andreia Jorge is research doctorate at the University of Coimbra. She obtained her PhD in macromolecular chemistry in 2013 from the University of Coimbra. During her PhD, she also worked at the Faculty of Pharmacy, University of Barcelona, and the Faculty of Chemistry and Pharmacy, University of Ludwig–Maximilians, Germany. She then moved to a postdoctoral fellow position in a joint project with the Coimbra Chemistry Centre and the Institute of Advanced Chemistry of Catalonia, Spain, where she conducted research on the chemical modification of oligonucleotides with therapeutic applications, using both experimental and computational approaches. Her current research activities are in the fields of chemical-modified therapeutic oligonucleotides (antisense and siRNA) for gene silencing, antiproliferative oligonucleotides, sequence‐specific protein–DNA interactions, lipid- and polymer-based drug delivery systems and programmable self-assembling DNA nanostructures. 
Alberto A. C. C. Pais is full professor of chemistry and head of the Department of Chemistry, University of Coimbra. He is also head of the Macromolecular, Colloids and Photochemistry Group, Coimbra Chemical Center (in collaboration with the Multicomponent Systems lab, a part of that group). He has published 14 book chapters, 2 books and 200 articles in international peer-reviewed journals. His scientific interests are vast and include chemometrics, pharmaceutical technology, molecular modeling/simulation and data science.

Descriere

This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. It  encompasses general aspects pertaining to fundamental development, as well as a diversity of nanomedicines applied in treatment and/or diagnosis.