In this issue of Neurologic Clinics, guest editor Dr. Alejandro A. Rabinstein brings his considerable expertise to the topic of Neurocritical Care. Top experts cover key topics in the field, including ICU delirium: a neurological perspective; prolonged monitoring of brain electrical activity in the ICU; AI applications in neurocritical care; brain injury after cardiac arrest: refining prognosis; advances in the critical care of ischemic brain infarction; and many more.