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Neurologic Channelopathies: Handbook of Clinical Neurology, cartea 203

Michael G. Hanna
en Limba Engleză Hardback – 27 sep 2024
Neurological Channelopathies, Volume 203 begins with an introductory overview highlighting common mechanistic themes that cut across different CNS and PNS presentations, but that also have potential for common treatment approaches, considering classification, genetics, and fundamental physiology of ion channels. Subsequent chapters present a detailed consideration of all genetic and immunological channelopathies. Each chapter considers Pathophysiological underpinnings - genetic or immunological; Clinical presentations; Diagnostic approach; and Treatment and management.

In the last 15 years, a combination of detailed clinical, genetic, molecular electrophysiological, and immunological research has combined to result in a deep understanding of a subgroup of neurological diseases spanning the central and peripheral nervous system and which have become known collectively as the Neurological Channelopathies. Although it was originally considered that significant ion channel dysfunction would not be compatible with life, we now know this is often not the case, although severe disease can often be the result. Given these major advances, it is now the right time to combine this knowledge into a single HCN volume dedicated to the topics at hand.

  • Identifies importance of ion channels to CNS & PNS function
  • Considers the classification, genetics, and physiology of ion channels
  • Presents all major immunological and genetic channelopathies
  • Provides clinical presentation, diagnosis, and treatment of channelopathies
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Specificații

ISBN-13: 9780323908207
ISBN-10: 0323908209
Pagini: 292
Dimensiuni: 192 x 262 mm
Editura: ELSEVIER SCIENCE
Seria Handbook of Clinical Neurology


Cuprins

1. Structure-function and pharmacological aspects of ion channels relevant to neurologic channelopathies 2. Inherited Myotonias 3. Periodic Paralysis 4. Andersen-Tawil syndrome 5. Congenital myasthenic syndromes 6. Human pain channelopathies 7. Pediatric Neuromuscular Channelopathies 8. The Episodic Ataxias 9. Familial Hemiplegic Migraine 10. Paroxysmal Movement Disorders 11. Epilepsies 12. Myasthenia Gravis 13. Neuromyotonia 14. Stiff person Syndrome 15. Autoantibody-mediated central nervous system channelopathies