This volume constitutes the refereed proceedings of 13 international workshops held as part of OTM 2008 in Monterrey, Mexico, in November 2008. The 106 revised full papers presented were carefully reviewed and selected from a total of 171 submissions to the workshops. The volume starts with 19 additional revised poster papers of the OTM 2008 main conferences CoopIS and ODBASE. Topics of the workshop papers are ambient data integration (ADI 2008), agents and web services merging in distributed environment (AWeSoMe 2008), community-based evolution of knowledge-intensive systems (COMBEK 2008), enterprise integration, interoperability and networking (EI2N 2008), system/software architectures (IWSSA 2008), mobile and networking technologies for social applications (MONET 2008), ontology content and evaluation in enterprise & quantitative semantic methods for the internet (OnToContent and QSI 2008), object-role modeling (ORM 2008), pervasive systems (PerSys 2008), reliability in decentralized distributed systems (RDDS 2008), semantic extensions to middleware enabling large scale knowledge (SEMELS 2008), and semantic Web and Web semantics (SWWS 2008).