Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition
Autor Richard B. Silvermanen Limba Engleză Hardback – 6 mar 2002
This is a revised edition of a very successful book, which appeals to both academic and industrial markets.
- Illustrates the organic mechanism associated with each enzyme-catalyzed reaction
- Makes the connection between organic reaction mechanisms and enzyme mechanisms
- Compiles the latest information about molecular mechanisms of enzyme reactions
- Accompanied by clearly drawn structures, schemes, and figures
- Includes an extensive bibliography on enzyme mechanisms covering the last 30 years
- Explains how enzymes can accelerate the rates of chemical reactions with high specificity
- Provides approaches to the design of inhibitors of enzyme-catalyzed reactions
- Categorizes the cofactors that are appropriate for catalyzing different classes of reactions
- Shows how chemical enzyme models are used for mechanistic studies
- Describes catalytic antibody design and mechanism
- Includes problem sets and solutions for each chapter
- Written in an informal and didactic style
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Specificații
ISBN-13: 9780126437317
ISBN-10: 0126437319
Pagini: 736
Ilustrații: illustrations
Dimensiuni: 152 x 229 x 53 mm
Greutate: 1.25 kg
Ediția:Rev
Editura: ELSEVIER SCIENCE
ISBN-10: 0126437319
Pagini: 736
Ilustrații: illustrations
Dimensiuni: 152 x 229 x 53 mm
Greutate: 1.25 kg
Ediția:Rev
Editura: ELSEVIER SCIENCE
Public țintă
Upper division undergraduate and postgraduate students in the fields of chemistry (organic and medicinal) and biochemistry; Industrial chemists who want to learn about enzyme-catalyzed reactions for the design of enzyme inhibitors (pharmaceutical and agricultural industries)Cuprins
Enzymes as Catalysts
Group Transfer Reactions: Hydrolysis, Amination, Phosphorylation
Reduction and Oxidation
Monooxygenation
Dioxygenation
Substitutions
Carboxylations
Decarboxylation
Isomerizations
Eliminations and Additions
Aldol and Claisen Reactions and Retroreactions
Formylations, Hydroxymethylations, and Methylations
Rearrangements
Appendix I Enzyme Kinetics
Appendix II Problems and Solutions
Group Transfer Reactions: Hydrolysis, Amination, Phosphorylation
Reduction and Oxidation
Monooxygenation
Dioxygenation
Substitutions
Carboxylations
Decarboxylation
Isomerizations
Eliminations and Additions
Aldol and Claisen Reactions and Retroreactions
Formylations, Hydroxymethylations, and Methylations
Rearrangements
Appendix I Enzyme Kinetics
Appendix II Problems and Solutions
Recenzii
Praise for the First Edition:
"Silverman's newest contribution will serve as an outstanding text and reference on the reaction mechanisms of enzymes. ... His treatment of the topic should also appeal to a broad range of organic, medicinal, and biological chemists who desire an up-to-date and succinct overview of the field. Silverman should be congratulated ... should quickly become the standard for mechanistic studies." --JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
"Silverman's newest contribution will serve as an outstanding text and reference on the reaction mechanisms of enzymes. ... His treatment of the topic should also appeal to a broad range of organic, medicinal, and biological chemists who desire an up-to-date and succinct overview of the field. Silverman should be congratulated ... should quickly become the standard for mechanistic studies." --JOURNAL OF THE AMERICAN CHEMICAL SOCIETY