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Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition

Autor Richard B. Silverman
en Limba Engleză Hardback – 6 mar 2002
The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed.
This is a revised edition of a very successful book, which appeals to both academic and industrial markets.


  • Illustrates the organic mechanism associated with each enzyme-catalyzed reaction
  • Makes the connection between organic reaction mechanisms and enzyme mechanisms
  • Compiles the latest information about molecular mechanisms of enzyme reactions
  • Accompanied by clearly drawn structures, schemes, and figures
  • Includes an extensive bibliography on enzyme mechanisms covering the last 30 years
  • Explains how enzymes can accelerate the rates of chemical reactions with high specificity
  • Provides approaches to the design of inhibitors of enzyme-catalyzed reactions
  • Categorizes the cofactors that are appropriate for catalyzing different classes of reactions
  • Shows how chemical enzyme models are used for mechanistic studies
  • Describes catalytic antibody design and mechanism
  • Includes problem sets and solutions for each chapter
  • Written in an informal and didactic style
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Specificații

ISBN-13: 9780126437317
ISBN-10: 0126437319
Pagini: 736
Ilustrații: illustrations
Dimensiuni: 152 x 229 x 53 mm
Greutate: 1.25 kg
Ediția:Rev
Editura: ELSEVIER SCIENCE

Public țintă

Upper division undergraduate and postgraduate students in the fields of chemistry (organic and medicinal) and biochemistry; Industrial chemists who want to learn about enzyme-catalyzed reactions for the design of enzyme inhibitors (pharmaceutical and agricultural industries)

Cuprins

Enzymes as Catalysts
Group Transfer Reactions: Hydrolysis, Amination, Phosphorylation
Reduction and Oxidation
Monooxygenation
Dioxygenation
Substitutions
Carboxylations
Decarboxylation
Isomerizations
Eliminations and Additions
Aldol and Claisen Reactions and Retroreactions
Formylations, Hydroxymethylations, and Methylations
Rearrangements
Appendix I Enzyme Kinetics
Appendix II Problems and Solutions

Recenzii

Praise for the First Edition:
"Silverman's newest contribution will serve as an outstanding text and reference on the reaction mechanisms of enzymes. ... His treatment of the topic should also appeal to a broad range of organic, medicinal, and biological chemists who desire an up-to-date and succinct overview of the field. Silverman should be congratulated ... should quickly become the standard for mechanistic studies." --JOURNAL OF THE AMERICAN CHEMICAL SOCIETY