This volume highlights the analysis on noncompact and singular manifolds within the framework of the cone calculus with asymptotics. The three papers at the beginning deal with parabolic equations, a topic relevant for many applications. The first article presents a calculus for pseudodifferential operators with an anisotropic analytic parameter. The subsequent paper develops an algebra of Mellin operators on the infinite space-time cylinder. It is shown how timelike infinity can be treated as a conical singularity. In the third text - the central article of this volume - the authors use these results to obtain precise information on the long-time asymptotics of solutions to parabolic equations and to construct inverses within the calculus. There follows a factorization theorem for meromorphic symbols: It is proven that each of these can be decomposed into a holomorphic invertible part and a smoothing part containing all the meromorphic information. It is expected that this result will be important for applications in the analysis of nonlinear hyperbolic equations. The final article addresses the question of the coordinate invariance of the Mellin calculus with asymptotics.