In this issue of Neurologic Clinics, guest editor Dr. Joseph Jankovic brings his considerable expertise to the topic of Parkinson's Disease. Top experts cover key topics in the field, including James Parkinson and other historical aspects of Parkinson’s disease; precision medicine in Parkinson’s disease; prodromal Parkinson’s disease; biomarkers in Parkinson’s disease; disease-modifying therapies in Parkinson’s disease; and many more.