In this issue of Oral and Maxillofacial Surgery Clinics, guest editor Dr. Seenu Susarla brings his considerable expertise to the topic of Pediatric Craniomaxillofacial Pathology. Top experts in the field discuss non-trauma management of craniomaxillofacial conditions, including soft tissue lesions, cysts and tumors, odontogenic infections, vascular anomalies, and head and neck malignancies. The issue begins with an important article on “A Conceptual Framework for the Differential Diagnosis of Pediatric Craniomaxillofacial Lesions,” which sets the stage for the subsequent articles.