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Phenotypes and Genotypes: The Search for Influential Genes: Computational Biology, cartea 18

Autor Florian Frommlet, Małgorzata Bogdan, David Ramsey
en Limba Engleză Hardback – 24 feb 2016
Thistimely text presents a comprehensive guide to genetic association, a new andrapidly expanding field that aims to elucidate how our genetic code (genotypes)influences the traits we possess (phenotypes). The book provides a detailedreview of methods of gene mapping used in association with experimentalcrosses, as well as genome-wide association studies. Emphasis is placed onmodel selection procedures for analyzing data from large-scale genome scansbased on specifically designed modifications of the Bayesian informationcriterion. Features: presents a thorough introduction to the theoreticalbackground to studies of genetic association (both genetic and statistical); reviewsthe latest advances in the field; illustrates the properties of methods formapping quantitative trait loci using computer simulations and the analysis ofreal data; discusses open challenges; includes an extensive statisticalappendix as a reference for those who are not totally familiar with thefundamentals of statistics.

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Specificații

ISBN-13: 9781447153092
ISBN-10: 144715309X
Pagini: 300
Ilustrații: XII, 222 p. 33 illus., 20 illus. in color.
Dimensiuni: 155 x 235 x 14 mm
Greutate: 0.51 kg
Ediția:1st ed. 2016
Editura: SPRINGER LONDON
Colecția Springer
Seria Computational Biology

Locul publicării:London, United Kingdom

Public țintă

Research

Cuprins

Introduction.- A Primer in Genetics.- Statistical Methods in High Dimensions.- Statistical Methods of QTL Mapping for Experimental Populations.- Statistical Analysis of GWAS.- Appendix A: Basic Statistical Distributions.- Appendix B: Basic Methods of Estimation.- Appendix C: Principles of Statistical Testing.- Appendix D: Elements of Bayesian Statistics.- Appendix E: Other Statistical Methods.

Notă biografică

Dr. Florian Frommlet is a researcher in the Center for Medical Statistics, Informatics, and Intelligent Systems at the Medical University of Vienna, Austria.
Dr. Małgorzata Bogdan is an Associate Professor in the Institute of Mathematics at Wrocław University, Poland.
Dr. David Ramsey is a Senior Lecturer in the Department of Operations Research at Wrocław University of Technology, Poland.

Textul de pe ultima copertă

This timely text presents a comprehensive guide to geneticassociation, a new and rapidly expanding field that aims to elucidate how ourgenetic code (genotypes) influences the traits we possess (phenotypes). Thebook provides a detailed review of methods of gene mapping used in associationwith experimental crosses, as well as genome-wide association studies. Emphasisis placed on model selection procedures for analyzing data from large-scalegenome scans based on specifically designed modifications of the Bayesianinformation criterion.
Topics and features:

  • Presents a thorough introduction to the theoreticalbackground to studies of genetic association (both genetic and statistical)
  • Reviews the latest advances in the field, highlighting theadvantages and shortcomings of the currently most commonly used methods
  • Illustrates the properties of methods for mappingquantitative trait loci using computer simulations and the analysis of realdata
  • Discusses open challenges that remain to be solved in thefuture
  • Includes an extensive statistical appendix as a referencefor those who are not totally familiar with the fundamentals of statistics
This important work is essential reading for researchers andgraduate students wishing to enter the field of statistical genetics and/orinterested in statistical issues related to the analysis of high-dimensionaldata. No prior background knowledge of genetics is required, although somebasic mathematical and computer science skills are assumed.
Dr. Florian Frommlet is a researcher in the Center forMedical Statistics, Informatics, and Intelligent Systems at the MedicalUniversity of Vienna, Austria. Dr. Małgorzata Bogdan is an Associate Professorin the Institute of Mathematics at Wrocław University, Poland. Dr. David Ramseyis a Senior Lecturer in the Department of Operations Research at WrocławUniversity of Technology, Poland.


Caracteristici

Introduces the major concepts of Quantitative Trait Loci mapping Discusses the methodology of Quantitative Trait Loci mapping in experimental populations Describes the methods for Genome Wide Association Studies and related multiple testing and model selection problems Includes supplementary material: sn.pub/extras