Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2

Synthesis and Activity of Platinum Compounds: NMR Spectroscopy of Platinum Drugs: From DNA to Body Fluids (K.J. Barnham et al.). Transdiamminedichloroplatinum (II) Is Not an Antitumor Drug: Why? (R. Dalbiès et al.). Iminoethers as Carrier Ligands: A Novel Transplatinum Complex Possessing in Vitro and in Vivo Antitumor Activity (M. Coluccia et al.). Molecular Dynamics Simulations on Cisplatin Adducts with Dinucleotides (J. Kozelka). Orally Active DACHPt (IV) Compounds (Y. Kidani et al.). Clinical Pharmacology: Pharmacokinetic-Pharmacodynamic Relationships (P. Canal, E. Chatelut). Clinical Pharmacology of Carboplatin Administered in Alternating Sequence with Paclitaxel in Patients with Nonsmall Cell Lung Cancer: A European Cancer Centre (ECC) Study (L.J.C. van Warmerdam et al.). The Clinical Development of the Oral Platinum Anticancer Agent JM216 (I. Judson et al.). Biochemistry and Molecular Pharmacology: Membrane Transportof Platinum Compounds (G. Los et al.). Detection of Adducts Formed upon Treatment of DNA with Cisplatin and Carboplatin (A.M.J. FichtingerSchepman et al.). Detection of Platinum Lesions at the Nucleotide Level in Cells Using Single Strand Ligation PCR (J.A. Hartley et al.). A Review of the Modulation ofCisplatin Toxicities by Chemoprotectants (R.T. Dorr). CombinationTherapy with Cisplatinum and EGF Receptor Blockade (J. Mendelsohnet al.). Clinical Studies: Oxaliplatin: Update on an Activeand Safe Dach Platinum Complex (P. Soulié et al.). Combination of Different Platinum Compounds: Issues, Strategies and Experience (F.M. Muggia). Phase I and II Studies with Lobaplatin (H. Fiebig). Phase I Trials of Ormaplatin (NSC 363812)(M.C. Christian). 254S, NK121 and TRK710 (M. Ogawa). Clinical Trials of Oxaliplatin and DWA2114R (T. Taguchi). Incorporating Assessments of Sequencedependence in Developmental Studies of CombinationChemotherapy Regimens Containing New Agents and Platinum Compounds (E.K. Rowinsky). Review of Carboplatinbased Highdose Chemotherapy Combinations in the Autotransplant Setting(S. Rodenhuis et al.). Treatment Intensification in Germcell Tumors (J.P. Droz et al.). Nonplatinum Metal Complexes: Overview of Tumorinhibiting Nonplatinum Complexes (B.K. Keppler, E.A. Vogel). Phenotypic Aspects of Platinum Resistance (T. Fojo et al.). How Does Platinum Kill the Cell? The Cisplatininduced Cellular Injury Response (S.B. Howell et al.). Controversy Session: Cisplatin vs. Carboplatin? Carboplatinvs. Cisplatin in the Chemotherapy of Solid Tumors: Procarboplatin (D.S. Alberts). Cisplatin and Carboplatin in Testis and Ovarian Cancer: Procisplatin (S.D. Williams). Resistance: Hypersensitivity to Cisplatin in Mouse LeukemiaL1210/0 Cells: An XPG DNA Repair Defect (R. Wood et al.). 4 additional articles. Index.