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Polymers in Drug Delivery

Editat de Ijeoma F. Uchegbu, Andreas G. Schatzlein
en Limba Engleză Paperback – 2 dec 2019
Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we’ve seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene therapy. While Polymers in Drug Delivery offers much new insight for the veteran specialist, this work has been compiled with the non-specialist in mind. It includes contributions from many of the world’s leading drug delivery specialists, yet avoids jargon and presents background information that initiates the next generation of scientists into the amazing work going on at the frontiers of this rapidly evolving science.
Targeting specific issues at the forefront of drug delivery today, this engaging volume—
·         Outlines the issues that must be considered when selecting a polymer for fabricating a drug delivery agent or other medical devices
·         Explains the more commonly used methods by which polymers may be characterized prior to use
·         Profiles polymer matrices that have been used in the formulation of solid oral dosage forms, drug delivery scaffolds, and hydrogels
·         Examines the issues surrounding the encapsulation of biologics within microspheres
·         Explores the use of nanoparticulates, especially solid nanoparticles and nanocapsules prepared from largely-water-insoluble cyanoacrylate polymers
·         Discusses polymeric micelles and investigates the potential of soluble polymer prodrugs and polymer nanomedicines
·         Details the contribution made by polymers and dendrimers to the gene delivery effort, which may one day lead to effective treatments for  largely incurable diseases 
Noting a dramatic paradigm shift that is bridging the gap between materials science and life science, the editors have compiled this volume to paint an interdisciplinary portrait of drug delivery that will challenge young scientists to turn their attention and effort towards this critical branch of biomedicine. Containing state-of-the-art information for drug delivery scientists, it is also a great choice for medical and  pharmaceutical students and others seeking an in-depth introduction to the field.
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Specificații

ISBN-13: 9780367453596
ISBN-10: 0367453592
Pagini: 276
Ilustrații: 93
Dimensiuni: 178 x 254 mm
Greutate: 0.45 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press

Public țintă

Academic, Professional, and Professional Practice & Development

Cuprins

Preface: Drug Delivery – Yesterday and Today. Introduction. Selecting the Right Polymer for Biomaterials Applications. Polymer Characterizations Techniques. The Role of Polymers in Solid Oral Dosage Forms. Hydrogel Drug Delivery Systems. An Assessment of the Role of Polymers for Drug Delivery in Tissue Engineering. Poly (lactic-co-glycolic acid) Microspheres. Polymeric Nanoparticles as Drug Carriers. Polymeric Micelles as Pharmaceutical Carriers. Polymeric Vesicles. Polymer-Drug Conjugates. Polymers Used for the Delivery of Genes in Gene Therapy. Dendrimers in Drug and Gene Delivery.

Notă biografică

Uchegbu\, Ijeoma F.; Schatzlein\, Andreas G.

Recenzii

“… explains the role of polymers in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. It contains 13 chapters, which cover different aspects of polymers in drug delivery. … The book is ideally suited for medical and pharmaceutical scientists and students. ”
— John F. Kennedy, Zaheera Parveen, Chembiotech Laboratories, Institute of Research and Development, University of Birmingham Research Park, UK, in International Journal of Biological Macromolecules, Vol. 41, 2007

Descriere

In recent years there has been an explosion in the use of polymers to solve various biomedical problems. Polymers play a crucial role in controlling drug release rate, enhancing drug solubility and uptake, and limiting drug degradation and toxicity. Polymers in Drug Delivery is a state-of-the-art documentation and review of all areas in which polymers are used in drug delivery, including hydrogels, soluble polymer drug conjugates, polymeric vesicles and micelles, microspheres, nanoparticles, polymeric in tissue engineering, and more. It is a readily accessible volume suitable for drug delivery scientists and as reading for advanced pharmaceutical students and others new to the field.