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Prions and Diseases: Volume 2, Animals, Humans and the Environment de Wen-Quan Zou

Prions and Diseases: Volume 2, Animals, Humans and the Environment

Editat de Wen-Quan Zou, Pierluigi Gambetti
en Limba Engleză Hardback – 8 noi 2012
Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.
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Specificații

ISBN-13: 9781461453376
ISBN-10: 1461453372
Pagini: 308
Ilustrații: X, 298 p.
Dimensiuni: 155 x 235 x 21 mm
Greutate: 5.8 kg
Ediția:2013
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States

Public țintă

Research

Cuprins

Chapter 1    Bovine Spongiform Encephalopathy
Gianluigi Zanusso, Salvatore Monaco
Chapter 2    Classical and Atypical Scrapie in Sheep and Goats
Christine Fast, Martin H. Groschup
Chapter 3 Chronic wasting disease and the development of research models
Glenn Telling
Chapter 4    Sporadic Human Prion Disease
Pierluigi Gambetti
Chapter 5    Environmentally-acquired Transmissible Spongiform Encephalopathy
Paul Brown
Chapter 6    Prions in the Environment
Shannon L. Bartelt-Hunt, Jason C. Bartz, Samuel E. Saunders
Chapter 7    The Spectrum of Tau Pathology in Human Prion Disease
Gabor G. Kovacs, Herbert Budka
Chapter 8    Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion
Alexander H. Peden, Mark W. Head, James W. Ironside
Chapter 9   Species Barriers in Prion Disease
Suzette A. Priola
Chapter 10    Transgenic Mice Modelling
Abigail B. Diack, Rona Wilson, Enrico Cancellotti, Barry Bradford, Matthew Bishop, Jean C. Manson
Chapter 11  Prion Transmission Studies in Transgenic Mice
Qingzhong Kong
 
Chapter 12  Alternative Models of Prion Diseases
Pedro Fernandez-Funez, Edward Málaga-Trillo, Diego E. Rincon-Limas
Chapter 13  Diagnosis of Prion Disease: Conventional Approaches
Inga Zerr, Joanna Gawinecka, Katharina Stoeck, Maren Breithaupt
Chapter 14  Quaking-induced Conversion (QuIC) Assays for the Detection and Diagnosis of Prion Diseases
Jason M. Wilham, Christina D. Orrù, Sarah Vascellari, Andrew G. Hughson, Byron Caughey
Chapter 15 The Tyr-Tyr-Arg Prion-Specific Epitope: Update and Context
T. Dean Airey, and Neil R. Cashman
Chapter 16  Overview on Treatment of Prion Diseases and Decontamination of Prions
Richard Knight
Chapter 17  Immunomodulation
Thomas Wisniewski, Fernando Goñi

Textul de pe ultima copertă

Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrPSc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases.
Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

Caracteristici

Authored by a team of leading researchers and clinicians
Updated knowledge and concepts on pathogenic prion proteins and prion diseases
Present state-of the art findings and hypotheses beyond prions and prion diseases
Includes supplementary material: sn.pub/extras

Notă biografică

Wen-Quan Zou, MD, PhD is Professor of Pathology at Case Western University School of Medicine, and he is Associate Director of the National Prion Disease Pathology Surveillance Center.
 
Pierluigi Gambetti, MD, is Professor of Pathology and Neurology at Case Western University School of Medicine.