This book gathers the latest fundamental research contributions, innovations, and applications in the field of design and analysis of complex robotic mechanical systems, machines, and mechanisms, as presented by leading researchers at the combined IFToMM Symposium of RoManSy and USCToMM Symposium on Mechanical Systems and Robotics (MSR-RoManSy), held in St. Petersburg, FL, USA, on May 22–25, 2024. It covers highly diverse topics, including soft, wearable, and origami robotic systems; applications to walking, flying, climbing, underground, swimming, and space systems; human rehabilitation and performance augmentation; design and analysis of mechanisms and machines; human–robot collaborative systems; service robotics; mechanical systems and robotics education; and the commercialization of mechanical systems and robotics. The contributions, which were selected by means of a rigorous international peer-review process, highlight numerous exciting and impactful research results that will inspire novel research directions and foster multidisciplinary research collaborations among researchers from around the globe.