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Progress in the Chemistry of Organic Natural Products 102: Progress in the Chemistry of Organic Natural Products, cartea 102

Editat de A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun'ichi Kobayashi
en Limba Engleză Hardback – 15 iul 2016
The first contribution reviews the phytochemical, chemical,and biological literature on members of the ingenane class of diterpenoids fromtheir first isolation in 1968 through 2015, highlighting unresolved issues bothcommon to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in thelight of the Jakupovic proposal of a dissection between the formation of the macrocyclicEuphorbia diterpenoids and the phorboids,and the clinical development of ingenol mebutate is chronicled in the light ofits “reverse-pharmacology” focus.
The second contributionoffers a comprehensive view of the chemical wealth and the taxonomic problemscurrently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth andpopulation dynamics of the genus, as well as its chemical diversity and ecologicalrelations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.
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Specificații

ISBN-13: 9783319331706
ISBN-10: 3319331701
Pagini: 200
Ilustrații: V, 252 p. 190 illus., 10 illus. in color.
Dimensiuni: 155 x 235 mm
Ediția:1st ed. 2016
Editura: Springer International Publishing
Colecția Springer
Seria Progress in the Chemistry of Organic Natural Products

Locul publicării:Cham, Switzerland

Cuprins

The Laurencia paradox:an endless source of chemodiversity. - Ingenane Dipernoids.

Textul de pe ultima copertă

The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its “reverse-pharmacology” focus.
The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.

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Written by recognized authorities in the fields Providing comprehensive and up-to-date reviews in the topic Well-known series