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Prostate Cancer: Shifting from Morphology to Biology de Stefania Staibano

Prostate Cancer: Shifting from Morphology to Biology

Editat de Stefania Staibano
en Limba Engleză Hardback – 23 sep 2013
The aim of this book will be to contribute to the education of a new generation of experts in urology, molecular biology, pathology and oncology, offering them sufficient knowledge in basic and translational research to be fluency in the web of interacting networks playing a role in prostate cancer development, progression, metastasis and drug-resistance.The volume will cover the latest innovative researches in prostate cancer, with particular emphasis to the state-of-the-art analysis technologies that are essential for the accurate identification of molecular targets for disease diagnosis, molecular mechanisms of tumorigenesis, markers for susceptibility, molecular-based prognostic prevision, characterization of biomarkers of drug efficacy and drug resistance, validation of new therapeutics and diagnostics. Current advancements on the intersecting data concerning transcriptomes, proteomes, the molecular techniques referred as "omes", will be reported and discussed.
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Specificații

ISBN-13: 9789400771482
ISBN-10: 9400771487
Pagini: 316
Ilustrații: XVIII, 296 p. 41 illus., 38 illus. in color.
Dimensiuni: 155 x 235 x 23 mm
Greutate: 0.75 kg
Ediția:2013
Editura: SPRINGER NETHERLANDS
Colecția Springer
Locul publicării:Dordrecht, Netherlands

Public țintă

Graduate

Cuprins

Foreword. Preface. List of contributors. I Clues to morphological diagnosis and prognosis evaluation.-Update on diagnostic criteria, on biopsy and surgical specimen: pre-invasive lesions, from epithelial cell hyperplasia to carcinoma in situ invasive carcinoma. First-line immunophenotyping of prostate diseases.- II Molecular pathology.- Molecular determinants of cancer-related inflammation.- Apoptosis and autophagy.- Androgen receptor and steroidogenesis pathways.- Neuroendocrine differentiation – role of somatostatin receptors (SSTRs) for diagnosis, prognosis, and therapy.- Metastatic dissemination.- Resistance to castration - resistance to drugs.- Crossroads of signaling pathways. III Genetic and Epigenetic Events in prostate cancer.- Gene polymorphisms.- Expression signature.- Mapping prostate cancer aggressiveness loci.- Epigenetic mechanisms: histone acetylation, DNA methylation, miRNA, chromatin modifiers. IV A modern approach to therapy of prostate cancer: targeting the deadly subset.-Molecular markers for patient selection and stratification: personalized prognostic predictive models.- Targeting tumor angiogenesis.- Efficacy of signal transduction inhibition in advanced prostate cancer.- Therapeutic targeting of the bone pre-metastatic niche.- Counteracting hypoxia in radio-resistant metastatic lesions.- “Synthetic lethality”: molecular co-targeting to restore the DNA.- Repair mechanisms in prostate cancer cells concluding remarks. Index.

Recenzii

From the reviews:
“A valuable compendium of salient topics in prostate cancer, this book encompasses the field, from diagnostic and prognostic criteria to current therapeutic approaches, while also offering valuable background in molecular pathology, genetics, and epigenetics. … ideally directed to urologists aiming to learn more about the intricacies of prostate cancer at the cellular and molecular level as well as bench scientists and biologists with an interest in a comprehensive perspective on the disease.” (Alessandro Fatatis, Doody’s Book Reviews, January, 2014)

Textul de pe ultima copertă

The aim of this book will be to contribute to the education of a new generation of experts in urology, molecular biology, pathology and oncology, offering them sufficient knowledge in basic and translational research to be fluency in the web of interacting networks playing a role in prostate cancer development, progression, metastasis and drug-resistance.The volume will cover the latest innovative researches in prostate cancer, with particular emphasis to the state-of-the-art analysis technologies that are essential for the accurate identification of molecular targets for disease diagnosis, molecular mechanisms of tumorigenesis, markers for susceptibility, molecular-based prognostic prevision, characterization of biomarkers of drug efficacy and drug resistance, validation of new therapeutics and diagnostics. Current advancements on the intersecting data concerning transcriptomes, proteomes, and the molecular techniques referred as "omes”, will be reported and discussed.

Caracteristici

Each chapter will prevede different levels of reading: brief introduction, main test and conclusions Detailed schemes of molecular pathways at the end of each chapter (where appropriate) The "dynamic" schemes of molecular pathways are available on the extra.springer.com website The most important references cited in each chapter will be marked in the reference section Includes supplementary material: sn.pub/extras