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Protein-Nucleic Acid Interactions: Structural Biology de Phoebe A. Rice

Protein-Nucleic Acid Interactions: Structural Biology: RSC Biomolecular Sciences

Editat de Phoebe A. Rice, Carl C. Correll
en Limba Engleză Hardback – 21 mai 2008
This book provides both in-depth background and up-to-date information in this area. The chapters are organized by general themes and principles, written by experts who illustrate topics with current findings. Topics covered include: the role of ions and hydration in protein-nucleic acid interactions; transcription factors and combinatorial specificity; indirect readout of DNA sequence; single-stranded nucleic acid binding proteins; nucleic acid junctions and proteins, RNA protein recognition; recognition of DNA damage. It will be a key reference for both advanced students and established scientists wishing to broaden their horizons.
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Specificații

ISBN-13: 9780854042722
ISBN-10: 0854042725
Pagini: 397
Dimensiuni: 165 x 236 x 36 mm
Greutate: 0.95 kg
Ediția:2008
Editura: Royal Society Of Chemistry
Colecția Royal Society of Chemistry
Seriile RSC Biomolecular Sciences, RSC Biomolecular Sciences (unnumbered)

Locul publicării:Cambridge, United States

Public țintă

Research

Descriere

This book provides both in-depth background and up-to-date information in this area. The chapters are organized by general themes and principles, written by experts who illustrate topics with current findings. Topics covered include:
- the role of ions and hydration in protein-nucleic acid interactions
- transcription factors and combinatorial specificity
- indirect readout of DNA sequence
- single-stranded nucleic acid binding proteins
- nucleic acid junctions and proteins,
- RNA protein recognition
- recognition of DNA damage.
It will be a key reference for both advanced students and established scientists wishing to broaden their horizons.

Cuprins

Chapter 1: Introduction; Chapter 2: The role of water and effects of small ions in site-specific protein-DNA interactions; Chapter 3: Structural Basis for Sequence-Specific DNA Recognition by Transcription Factors and their Complexes; Chapter 4: Indirect Readout Of DNA Sequence by Proteins; Chapter 5: Single-stranded Nucleic Acid (SSNA)-binding Proteins; Chapter 6: DNA junctions and their interaction with resolving enzymes; Chapter 7: RNA-protein Interactions in Ribonucleoprotein Particles and Ribonucleases; Chapter 8: Bending and compaction of DNA by proteins; Chapter 9: Mode of Action of Proteins with RNA Chaperone Activity; Chapter 10: Structure and Function of DNA Topoisomerases; Chapter 11: DNA Transposases; Chapter 12: Site-Specific Recombinases; Chapter 13: DNA Nucleases; Chapter 14: RNA-modifying enzymes

Caracteristici

The chapters organized by general themes and principles, written by experts
Topics covered include: the role of ions and hydration in protein-nucleic acid interactions, transcription factors and combinatorial specificity, indirect readout of DNA sequence, single-stranded nucleic acid binding proteins, nucleic acid junctions and proteins, RNA – protein recognition, and recognition of DNA damage
A key reference for both advanced students and established scientists

Textul de pe ultima copertă

The structural biology of protein - nucleic acid interactions is in some ways a mature field and in others in its infancy. Propelled by advances in technology as well as the realization of RNA's importance to biology, the number of example structures has ballooned in recent years. As a result of the explosion of research in this area, it is no longer possible to write a comprehensive review which makes it difficult for newcomers to the field to attain a solid understanding of the basics. One goal of this book is therefore to provide in-depth discussions of the fundamental principles of protein-nucleic interactions as well as to illustrate those fundamentals with up-to-date and fascinating examples for those who already possess some familiarity with the field. The book also emphasises the impact of structural biology on understanding how proteins interact with nucleic acids and it is intended for advanced students and established scientists wishing to broaden their horizons. A team of experts have been assembled to write the individual chapters of this book. The beginning chapters focus on more fundamental aspects of protein-nucleic acid interactions, such as thermodynamics and recognition strategies, while later chapters highlight more specialized topics in RNA and DNA metabolism, such as chaperones, modifying enzymes, topoisomerases, recombinases, and nucleases. Since it is impossible to cover all aspects of this rapidly expanding field, the editors have chosen to highlight a few topics that are fascinating in their own right while also providing a broad range of examples to underscore the basic principles.

Notă biografică

Dr Rice is an associate professor in the Department of Biochemistry & Molecular Biology at the University of Chicago. Having trained in the labs of Thomas Steitz at Yale and Kiyoshi Mizuuchi at NIH, she has a long-standing interest in the mechanisms and structural biology of DNA recombination. Dr Correll is an associate professor in the Department of Biochemistry & Molecular Biology at Rosalind Franklin University of Medicine and Science. Having trained in the labs of Profs. Martha Ludwig at the University of Michigan and Thomas Steitz at Yale University, he has a long-standing interest in structural biology. For the last decade his research has focused on how proteins cleave and/or rearrange the structure of RNA molecules.