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Quadruplex Nucleic Acids As Targets For Medicinal Chemistry de Stephen Neidle

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry: Annual Reports in Medicinal Chemistry, cartea 54

Stephen Neidle
en Limba Engleză Hardback – 25 aug 2020
The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.


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  • Presents the latest release in the Annual Reports in Medicinal Chemistry series
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Specificații

ISBN-13: 9780128210178
ISBN-10: 0128210176
Pagini: 564
Dimensiuni: 152 x 229 mm
Greutate: 0.92 kg
Editura: ELSEVIER SCIENCE
Seria Annual Reports in Medicinal Chemistry

Public țintă

Undergraduates, graduates, academics and researchers in the field of medicinal chemistry

Cuprins

Part 1. Fundamentals of quadruplexes and their biology
    1. Fundamentals of G-quadruplex biologyF. Brad Johnson
    2. Quadruplex structure and diversityFernaldo Richtia Winnerdy and Anh Tuân Phan
      Part 2. Quadruplex targets in human and other organisms
    3. Telomeric quadruplexes as therapeutic targetsSefan Asamitsu, Norifumi Shioda and Hiroshi Sugiyama
    4. Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapyEmanuela Ruggiero and Sara N. Richter
    5. Quadruplex detection in human cellsDavid Monchaud
      Part 3. Discovery and design of quadruplex-binding compounds
    6. An overview of quadruplex ligands: Their common features and chemotype diversityValentina Pirota, Michele Stasi, Alessandra Benassi and Filippo Doria
    7. Molecular dynamics simulations of G-quadruplexes: The basic principles and their application to folding and ligand bindingJiri Sponer, Barira Islam, Petr Stadlbauer and Shozeb Haider
    8. Quadruplex-interacting compounds for regulating the translation of the Epstein–Barr virus nuclear antigen 1 (EBNA1) mRNA: A new strategy to prevent and treat EBV-related cancersAnton Granzhan, Rodrigo Prado Martins, Robin Fåhraeus, Marc Blondel and Marie-Paule Teulade-Fichou
    9. Click and combinatorial approaches to quadruplex ligand discoveryJyotirmayee Dash, Puja Saha and Khushnood Fatma
    10. Quadruplex nucleic acids in KRAS targeted-cancer therapyLuigi E. Xodo
    11. Transcriptional regulation of MYC through G-quadruplex structuresSumirtha Balaratnam and John S. Schneekloth
    12. KIT promoter: Structure, function and targetingSilvia Ceschi and Claudia Sissi
    13. Quadruplex targets in neurodegenerative diseasesJanez Plavec
    14. Metal complexes as G-quadruplex bindersTim Kench and Ramon Vilar
    15. Challenges in developing small-molecule quadruplex therapeutics
Stephen Neidle